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Identification and comparison of RCMV ALL 03 open reading frame (ORF) among several different strains of cytomegalovirus worldwide

Overview of attention for article published in Infection, Genetics & Evolution, October 2017
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Title
Identification and comparison of RCMV ALL 03 open reading frame (ORF) among several different strains of cytomegalovirus worldwide
Published in
Infection, Genetics & Evolution, October 2017
DOI 10.1016/j.meegid.2017.06.020
Pubmed ID
Authors

Krishnan Nair Balakrishnan, Ashwaq Ahmed Abdullah, JamiluAbubakar Bala, Yusuf Abba, Siti Aimi Sarah, Faez Firdaus Abdullah Jesse, Zeenatul Allaudin Nazariah, Mohamed Mustapha Noordin, Mohd Lila Mohd-Azmi

Abstract

Rat cytomegalovirus ALL-03 (Malaysian strain) which was isolated from a placenta and uterus of a house rat, Rattus rattus diardii has the ability to cross the placenta and infecting the fetus. To further elucidate the pathogenesis of the Malaysian strain of Rat Cytomegalovirus ALL-03 (RCMV ALL-03), detailed analysis on the viral genome sequence is crucial. Genome sequencing of RCMV ALL-03 was carried out in order to identify the open reading frame (ORF), homology comparison of ORF with other strains of CMV, phylogenetic analysis, classifying ORF with its corresponding conserved genes, and determination of functional proteins and grouping of gene families in order to obtain fundamental knowledge of the genome. The present study revealed a total of 123 Coding DNA sequences (CDS) from RCMV ALL-03 with 37 conserved ORF domains as with all herpesvirus genomes. All the CDS possess similar function with RCMV-England followed by RCMV-Berlin, RCMV-Maastricht, and Human CMV. The phylogenetic analysis of RCMV ALL-03 based on conserving genes of herpes virus showed that the Malaysian RCMV isolate is closest to RCMV-English and RCMV-Berlin strains, with 99% and 97% homology, respectively. Similarly, it also demonstrated an evolutionary relationship between RCMV ALL-03 and other strains of herpesviruses from all the three subfamilies. Interestingly, betaherpesvirus subfamily, which has been shown to be more closely related with gammaherpesviruses as compared to alphaherpesviruses, shares some of the functional ORFs. In addition, the arrangement of gene blocks for RCMV ALL-03, which was conserved among herpesvirus family members was also observed in the RCMV ALL-03 genome. Genomic analysis of RCMV ALL-03 provided an overall picture of the whole genome organization and it served as a good platform for further understanding on the divergence in the family of Herpesviridae.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 20%
Student > Bachelor 2 13%
Student > Doctoral Student 2 13%
Researcher 2 13%
Professor 2 13%
Other 3 20%
Unknown 1 7%
Readers by discipline Count As %
Immunology and Microbiology 3 20%
Medicine and Dentistry 2 13%
Biochemistry, Genetics and Molecular Biology 2 13%
Agricultural and Biological Sciences 2 13%
Veterinary Science and Veterinary Medicine 1 7%
Other 3 20%
Unknown 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2017.
All research outputs
#10,672,843
of 12,034,939 outputs
Outputs from Infection, Genetics & Evolution
#1,405
of 1,810 outputs
Outputs of similar age
#226,453
of 269,135 outputs
Outputs of similar age from Infection, Genetics & Evolution
#39
of 47 outputs
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So far Altmetric has tracked 1,810 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.