Title |
Redox signaling in pathophysiology of hypertension
|
---|---|
Published in |
Journal of Biomedical Science, September 2013
|
DOI | 10.1186/1423-0127-20-69 |
Pubmed ID | |
Authors |
Miroslava Majzunova, Ima Dovinova, Miroslav Barancik, Julie YH Chan |
Abstract |
Reactive oxygen species (ROS) are products of normal cellular metabolism and derive from various sources in different cellular compartments. Oxidative stress resultant from imbalance between ROS generation and antioxidant defense mechanisms is important in pathogenesis of cardiovascular diseases, such as hypertension, heart failure, atherosclerosis, diabetes, and cardiac hypertrophy. In this review we focus on hypertension and address sources of cellular ROS generation, mechanisms involved in regulation of radical homeostasis, superoxide dismutase isoforms in pathophysiology of hypertension; as well as radical intracellular signaling and phosphorylation processes in proteins of the affected cardiovascular tissues. Finally, we discuss the transcriptional factors involved in redox-sensitive gene transcription and antioxidant response, as well as their roles in hypertension. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Slovenia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Unknown | 79 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 16 | 20% |
Student > Ph. D. Student | 9 | 11% |
Student > Bachelor | 9 | 11% |
Researcher | 7 | 9% |
Professor | 6 | 8% |
Other | 16 | 20% |
Unknown | 17 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 21% |
Agricultural and Biological Sciences | 13 | 16% |
Biochemistry, Genetics and Molecular Biology | 11 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Environmental Science | 3 | 4% |
Other | 10 | 13% |
Unknown | 20 | 25% |