You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pathogens and host immunity in the ancient human oral cavity
|
|---|---|
| Published in |
Nature Genetics, February 2014
|
| DOI | 10.1038/ng.2906 |
| Pubmed ID | |
| Authors |
Christina Warinner, João F Matias Rodrigues, Rounak Vyas, Christian Trachsel, Natallia Shved, Jonas Grossmann, Anita Radini, Y Hancock, Raul Y Tito, Sarah Fiddyment, Camilla Speller, Jessica Hendy, Sophy Charlton, Hans Ulrich Luder, Domingo C Salazar-García, Elisabeth Eppler, Roger Seiler, Lars H Hansen, José Alfredo Samaniego Castruita, Simon Barkow-Oesterreicher, Kai Yik Teoh, Christian D Kelstrup, Jesper V Olsen, Paolo Nanni, Toshihisa Kawai, Eske Willerslev, Christian von Mering, Cecil M Lewis, Matthew J Collins, M Thomas P Gilbert, Frank Rühli, Enrico Cappellini |
| Abstract |
Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past. |
X Demographics
The data shown below were collected from the profiles of 93 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 25 | 27% |
| United Kingdom | 18 | 19% |
| Germany | 3 | 3% |
| Canada | 2 | 2% |
| Denmark | 2 | 2% |
| Spain | 2 | 2% |
| Japan | 2 | 2% |
| Italy | 2 | 2% |
| Netherlands | 2 | 2% |
| Other | 9 | 10% |
| Unknown | 26 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 47 | 51% |
| Scientists | 35 | 38% |
| Practitioners (doctors, other healthcare professionals) | 7 | 8% |
| Science communicators (journalists, bloggers, editors) | 4 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 637 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 2% |
| Germany | 4 | <1% |
| Spain | 3 | <1% |
| Switzerland | 2 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| South Africa | 1 | <1% |
| Belgium | 1 | <1% |
| Other | 7 | 1% |
| Unknown | 604 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 138 | 22% |
| Researcher | 106 | 17% |
| Student > Master | 75 | 12% |
| Student > Bachelor | 62 | 10% |
| Student > Doctoral Student | 33 | 5% |
| Other | 118 | 19% |
| Unknown | 105 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 196 | 31% |
| Biochemistry, Genetics and Molecular Biology | 102 | 16% |
| Medicine and Dentistry | 51 | 8% |
| Arts and Humanities | 41 | 6% |
| Social Sciences | 32 | 5% |
| Other | 83 | 13% |
| Unknown | 132 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 215. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2021.
All research outputs
#184,336
of 25,784,004 outputs
Outputs from Nature Genetics
#273
of 7,623 outputs
Outputs of similar age
#1,472
of 240,652 outputs
Outputs of similar age from Nature Genetics
#5
of 74 outputs
Altmetric has tracked 25,784,004 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,623 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,652 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.