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Pathogens and host immunity in the ancient human oral cavity

Overview of attention for article published in Nature Genetics, February 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
15 news outlets
blogs
5 blogs
twitter
104 tweeters
facebook
3 Facebook pages
wikipedia
1 Wikipedia page
googleplus
2 Google+ users

Citations

dimensions_citation
325 Dimensions

Readers on

mendeley
508 Mendeley
citeulike
4 CiteULike
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Title
Pathogens and host immunity in the ancient human oral cavity
Published in
Nature Genetics, February 2014
DOI 10.1038/ng.2906
Pubmed ID
Authors

Christina Warinner, João F Matias Rodrigues, Rounak Vyas, Christian Trachsel, Natallia Shved, Jonas Grossmann, Anita Radini, Y Hancock, Raul Y Tito, Sarah Fiddyment, Camilla Speller, Jessica Hendy, Sophy Charlton, Hans Ulrich Luder, Domingo C Salazar-García, Elisabeth Eppler, Roger Seiler, Lars H Hansen, José Alfredo Samaniego Castruita, Simon Barkow-Oesterreicher, Kai Yik Teoh, Christian D Kelstrup, Jesper V Olsen, Paolo Nanni, Toshihisa Kawai, Eske Willerslev, Christian von Mering, Cecil M Lewis, Matthew J Collins, M Thomas P Gilbert, Frank Rühli, Enrico Cappellini

Abstract

Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.

Twitter Demographics

The data shown below were collected from the profiles of 104 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 508 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 12 2%
Germany 4 <1%
United Kingdom 3 <1%
Spain 3 <1%
Switzerland 2 <1%
Taiwan 1 <1%
Canada 1 <1%
South Africa 1 <1%
Belgium 1 <1%
Other 7 1%
Unknown 473 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 124 24%
Researcher 94 19%
Student > Master 67 13%
Student > Bachelor 50 10%
Professor 30 6%
Other 89 18%
Unknown 54 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 194 38%
Biochemistry, Genetics and Molecular Biology 80 16%
Medicine and Dentistry 42 8%
Arts and Humanities 33 6%
Social Sciences 25 5%
Other 62 12%
Unknown 72 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 222. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2019.
All research outputs
#92,817
of 17,617,388 outputs
Outputs from Nature Genetics
#168
of 6,660 outputs
Outputs of similar age
#1,032
of 194,838 outputs
Outputs of similar age from Nature Genetics
#2
of 67 outputs
Altmetric has tracked 17,617,388 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,660 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,838 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.