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X Demographics
Mendeley readers
Attention Score in Context
| Title |
In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease
|
|---|---|
| Published in |
Nature Medicine, February 2014
|
| DOI | 10.1038/nm.3462 |
| Pubmed ID | |
| Authors |
Raja Atreya, Helmut Neumann, Clemens Neufert, Maximilian J Waldner, Ulrike Billmeier, Yurdagül Zopf, Marcus Willma, Christine App, Tino Münster, Hermann Kessler, Stefanie Maas, Bernd Gebhardt, Ralph Heimke-Brinck, Eva Reuter, Frank Dörje, Tilman T Rau, Wolfgang Uter, Thomas D Wang, Ralf Kiesslich, Michael Vieth, Ewald Hannappel, Markus F Neurath |
| Abstract |
As antibodies to tumor necrosis factor (TNF) suppress immune responses in Crohn's disease by binding to membrane-bound TNF (mTNF), we created a fluorescent antibody for molecular mTNF imaging in this disease. Topical antibody administration in 25 patients with Crohn's disease led to detection of intestinal mTNF(+) immune cells during confocal laser endomicroscopy. Patients with high numbers of mTNF(+) cells showed significantly higher short-term response rates (92%) at week 12 upon subsequent anti-TNF therapy as compared to patients with low amounts of mTNF(+) cells (15%). This clinical response in the former patients was sustained over a follow-up period of 1 year and was associated with mucosal healing observed in follow-up endoscopy. These data indicate that molecular imaging with fluorescent antibodies has the potential to predict therapeutic responses to biological treatment and can be used for personalized medicine in Crohn's disease and autoimmune or inflammatory disorders. |
X Demographics
The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 8 | 18% |
| United States | 7 | 16% |
| Spain | 2 | 5% |
| Brazil | 2 | 5% |
| Belgium | 1 | 2% |
| Indonesia | 1 | 2% |
| Germany | 1 | 2% |
| Australia | 1 | 2% |
| Ireland | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 17 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 66% |
| Scientists | 9 | 20% |
| Practitioners (doctors, other healthcare professionals) | 3 | 7% |
| Science communicators (journalists, bloggers, editors) | 3 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 288 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 1% |
| United States | 3 | 1% |
| Germany | 2 | <1% |
| France | 1 | <1% |
| Malaysia | 1 | <1% |
| Israel | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 275 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 71 | 25% |
| Student > Ph. D. Student | 51 | 18% |
| Other | 22 | 8% |
| Student > Doctoral Student | 17 | 6% |
| Student > Bachelor | 16 | 6% |
| Other | 63 | 22% |
| Unknown | 48 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 98 | 34% |
| Agricultural and Biological Sciences | 43 | 15% |
| Biochemistry, Genetics and Molecular Biology | 20 | 7% |
| Immunology and Microbiology | 19 | 7% |
| Engineering | 14 | 5% |
| Other | 35 | 12% |
| Unknown | 59 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 59. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2023.
All research outputs
#738,975
of 25,863,888 outputs
Outputs from Nature Medicine
#2,102
of 9,459 outputs
Outputs of similar age
#6,795
of 240,717 outputs
Outputs of similar age from Nature Medicine
#18
of 95 outputs
Altmetric has tracked 25,863,888 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,459 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 105.9. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,717 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.