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The effect of infectious dose on humoral and cellular immune responses in Chlamydophila caviae primary ocular infection

Overview of attention for article published in PLOS ONE, July 2017
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Title
The effect of infectious dose on humoral and cellular immune responses in Chlamydophila caviae primary ocular infection
Published in
PLOS ONE, July 2017
DOI 10.1371/journal.pone.0180551
Pubmed ID
Authors

Ana Filipovic, Ehsan Ghasemian, Aleksandra Inic-Kanada, Ivana Lukic, Elisabeth Stein, Emilija Marinkovic, Radmila Djokic, Dejana Kosanovic, Nadine Schuerer, Hadeel Chalabi, Sandra Belij-Rammerstorfer, Marijana Stojanovic, Talin Barisani-Asenbauer

Abstract

Following infection, the balance between protective immunity and immunopathology often depends on the initial infectious load. Several studies have investigated the effect of infectious dose; however, the mechanism by which infectious dose affects disease outcomes and the development of a protective immune response is not known. The aim of this study was to investigate how the infectious dose modulates the local and systemic humoral and the cellular immune responses during primary ocular chlamydial infection in the guinea pig animal model. Guinea pigs were infected by ocular instillation of a Chlamydophila caviae-containing eye solution in the conjunctival sac in three different doses: 1×102, 1×104, and 1×106 inclusion forming units (IFUs). Ocular pathology, chlamydial clearance, local and systemic C. caviae-specific humoral and cellular immune responses were assessed. All inocula of C. caviae significantly enhanced the local production of C. caviae-specific IgA in tears, but only guinea pigs infected with the higher doses showed significant changes in C. caviae-specific IgA levels in vaginal washes and serum. On complete resolution of infection, the low dose of C. caviae did not alter the ratio of CD4+ and CD8+ cells within guinea pigs' submandibular lymph node (SMLN) lymphocytes while the higher doses increased the percentages of CD4+ and CD8+ cells within the SMLN lymphocytes. A significant negative correlation between pathology intensity and the percentage of CD4+ and CD8+ cells within SMLN lymphocyte pool at selected time points post-infection was recorded for both 1×104, and 1×106 IFU infected guinea pigs. The relevance of the observed dose-dependent differences on the immune response should be further investigated in repeated ocular chlamydial infections.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 14%
Researcher 2 14%
Student > Ph. D. Student 1 7%
Other 1 7%
Student > Master 1 7%
Other 1 7%
Unknown 6 43%
Readers by discipline Count As %
Immunology and Microbiology 3 21%
Veterinary Science and Veterinary Medicine 2 14%
Linguistics 1 7%
Nursing and Health Professions 1 7%
Medicine and Dentistry 1 7%
Other 0 0%
Unknown 6 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2017.
All research outputs
#16,556,653
of 20,585,116 outputs
Outputs from PLOS ONE
#138,152
of 177,664 outputs
Outputs of similar age
#211,537
of 281,788 outputs
Outputs of similar age from PLOS ONE
#2,603
of 3,331 outputs
Altmetric has tracked 20,585,116 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 177,664 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,788 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3,331 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.