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Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R

Overview of attention for article published in BMC Cancer, February 2014
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  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Mentioned by

twitter
3 tweeters

Citations

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101 Dimensions

Readers on

mendeley
64 Mendeley
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Title
Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R
Published in
BMC Cancer, February 2014
DOI 10.1186/1471-2407-14-134
Pubmed ID
Authors

Xing-Ming Ye, Hua-Yu Zhu, Wen-Dong Bai, Ting Wang, Lei Wang, Ying Chen, An-Gang Yang, Lin-Tao Jia

Abstract

Resistance to humanized monoclonal erbB2/HER2 antibody, trastuzumab (Herceptin), has become a pivotal obstacle for targeted therapy of HER2-positive breast cancers. The activation of alternative growth factor receptors, in particular, the insulin-like growth factor 1 receptor (IGF1R), represents a common feature of trastuzumab-refractory cells; however, the underlying mechanism remains elusive.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 2%
Portugal 1 2%
Poland 1 2%
Austria 1 2%
Unknown 60 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 31%
Student > Master 11 17%
Researcher 7 11%
Student > Bachelor 5 8%
Professor 2 3%
Other 10 16%
Unknown 9 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 27%
Biochemistry, Genetics and Molecular Biology 15 23%
Medicine and Dentistry 10 16%
Unspecified 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 7 11%
Unknown 11 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2014.
All research outputs
#13,709,189
of 22,747,498 outputs
Outputs from BMC Cancer
#3,127
of 8,273 outputs
Outputs of similar age
#113,110
of 221,189 outputs
Outputs of similar age from BMC Cancer
#56
of 141 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,273 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,189 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.