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Effects ofLactobacillus rhamnosusLA68 on the immune system of C57BL/6 mice upon oral administration

Overview of attention for article published in Journal of Dairy Research, February 2014
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1 tweeter

Citations

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16 Dimensions

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19 Mendeley
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Title
Effects ofLactobacillus rhamnosusLA68 on the immune system of C57BL/6 mice upon oral administration
Published in
Journal of Dairy Research, February 2014
DOI 10.1017/s0022029914000028
Pubmed ID
Authors

Rajna Dimitrijevic, Nevena Ivanovic, Geir Mathiesen, Vladimir Petrusic, Irena Zivkovic, Brizita Djordjevic, Ljiljana Dimitrijevic

Abstract

Probiotic bacteria have been used in human nutrition for centuries and are now attracting more attention. In order to examine the immunological aspects of probiotic consumption, Lactobacillus rhamnosus LA68 was orally administrated using gavage to healthy C57BL/6 mice. After one month splenocytes were isolated, and analysed by flow cytometry. The magnitude of splenocyte proliferation upon stimulation with lipopolysaccharide and peptidoglycan and cytokine levels (IFN-γ, IL-6, IL-10 and IL-17) was assessed. Cytokine levels in the serum were also analysed. Oral application of strain LA68 leads to a significant decrease of CD3+, CD25+ and CD19+ cells, and an increase of CD11b+ and CD16/CD32+ positive cell populations in the mouse spleen. Increased sensitivity to stimulation through proliferation and IL-6 secretion was detected. Increased serum IFN-γ and decreased IL-10 levels were found. Our results show increased responsiveness of splenocytes, activation of the Th1 type of immune response, and a shift of leucocyte populations towards monocyte/granulocyte populations.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 21%
Student > Ph. D. Student 3 16%
Other 2 11%
Student > Doctoral Student 1 5%
Student > Bachelor 1 5%
Other 3 16%
Unknown 5 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 32%
Biochemistry, Genetics and Molecular Biology 4 21%
Immunology and Microbiology 2 11%
Medicine and Dentistry 1 5%
Neuroscience 1 5%
Other 0 0%
Unknown 5 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2014.
All research outputs
#7,792,321
of 12,420,176 outputs
Outputs from Journal of Dairy Research
#328
of 444 outputs
Outputs of similar age
#98,419
of 189,837 outputs
Outputs of similar age from Journal of Dairy Research
#1
of 4 outputs
Altmetric has tracked 12,420,176 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 444 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,837 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them