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An Unexpected Role for the Clock Protein Timeless in Developmental Apoptosis

Overview of attention for article published in PLOS ONE, February 2011
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Title
An Unexpected Role for the Clock Protein Timeless in Developmental Apoptosis
Published in
PLOS ONE, February 2011
DOI 10.1371/journal.pone.0017157
Pubmed ID
Authors

Linda P. O'Reilly, Simon C. Watkins, Thomas E. Smithgall

Abstract

Programmed cell death is critical not only in adult tissue homeostasis but for embryogenesis as well. One of the earliest steps in development, formation of the proamniotic cavity, involves coordinated apoptosis of embryonic cells. Recent work from our group demonstrated that c-Src protein-tyrosine kinase activity triggers differentiation of mouse embryonic stem (mES) cells to primitive ectoderm-like cells. In this report, we identified Timeless (Tim), the mammalian ortholog of a Drosophila circadian rhythm protein, as a binding partner and substrate for c-Src and probed its role in the differentiation of mES cells.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 2 4%
Indonesia 1 2%
Portugal 1 2%
Brazil 1 2%
Sweden 1 2%
Unknown 41 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 30%
Researcher 10 21%
Student > Master 7 15%
Professor 4 9%
Professor > Associate Professor 3 6%
Other 5 11%
Unknown 4 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 55%
Biochemistry, Genetics and Molecular Biology 7 15%
Medicine and Dentistry 3 6%
Neuroscience 3 6%
Computer Science 1 2%
Other 2 4%
Unknown 5 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2015.
All research outputs
#18,366,246
of 22,747,498 outputs
Outputs from PLOS ONE
#154,387
of 194,162 outputs
Outputs of similar age
#93,476
of 105,997 outputs
Outputs of similar age from PLOS ONE
#1,100
of 1,284 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,162 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,997 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,284 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.