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Increased Inflammatory Signaling and Lethality of Influenza H1N1 by Nuclear Thioredoxin-1

Overview of attention for article published in PLOS ONE, April 2011
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1 Redditor

Citations

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34 Mendeley
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Title
Increased Inflammatory Signaling and Lethality of Influenza H1N1 by Nuclear Thioredoxin-1
Published in
PLOS ONE, April 2011
DOI 10.1371/journal.pone.0018918
Pubmed ID
Authors

Young-Mi Go, Sang-Moo Kang, James R. Roede, Michael Orr, Dean P. Jones

Abstract

Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immune cells. Excessive proinflammatory signaling in vivo contributes to immune hyper-responsiveness and disease severity, but no studies have addressed whether nuclear Trx1 mediates such responses.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 32%
Student > Doctoral Student 4 12%
Student > Postgraduate 4 12%
Student > Master 3 9%
Student > Ph. D. Student 3 9%
Other 3 9%
Unknown 6 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 29%
Medicine and Dentistry 5 15%
Neuroscience 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Other 2 6%
Unknown 10 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2011.
All research outputs
#20,143,522
of 22,649,029 outputs
Outputs from PLOS ONE
#172,522
of 193,361 outputs
Outputs of similar age
#101,397
of 108,269 outputs
Outputs of similar age from PLOS ONE
#1,356
of 1,439 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,361 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,269 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,439 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.