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Gold‐Triggered Uncaging Chemistry in Living Systems

Overview of attention for article published in Angewandte Chemie. International Edition, August 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#17 of 51,428)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
43 news outlets
blogs
2 blogs
twitter
32 X users
facebook
6 Facebook pages
reddit
1 Redditor
video
1 YouTube creator

Citations

dimensions_citation
135 Dimensions

Readers on

mendeley
153 Mendeley
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Title
Gold‐Triggered Uncaging Chemistry in Living Systems
Published in
Angewandte Chemie. International Edition, August 2017
DOI 10.1002/anie.201705609
Pubmed ID
Authors

Ana M. Pérez‐López, Belén Rubio‐Ruiz, Víctor Sebastián, Lloyd Hamilton, Catherine Adam, Thomas L. Bray, Silvia Irusta, Paul M. Brennan, Guy C. Lloyd‐Jones, Dirk Sieger, Jesús Santamaría, Asier Unciti‐Broceta

Abstract

Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled -for the first time- the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 153 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 27%
Student > Master 22 14%
Student > Bachelor 17 11%
Researcher 13 8%
Student > Doctoral Student 8 5%
Other 27 18%
Unknown 24 16%
Readers by discipline Count As %
Chemistry 86 56%
Agricultural and Biological Sciences 8 5%
Biochemistry, Genetics and Molecular Biology 7 5%
Pharmacology, Toxicology and Pharmaceutical Science 7 5%
Medicine and Dentistry 5 3%
Other 15 10%
Unknown 25 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 360. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2020.
All research outputs
#92,431
of 26,132,653 outputs
Outputs from Angewandte Chemie. International Edition
#17
of 51,428 outputs
Outputs of similar age
#2,051
of 332,768 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#2
of 806 outputs
Altmetric has tracked 26,132,653 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 51,428 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,768 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 806 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.