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Taurine 8

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Cover of 'Taurine 8'

Table of Contents

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    Book Overview
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    Chapter 1 Taurine, Glutathione and Bioenergetics
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    Chapter 2 Molybdenum Cofactor Deficiency: Metabolic Link Between Taurine and S-Sulfocysteine
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    Chapter 3 Taurine and chinese traditional medicine accelerate alcohol metabolism in mice.
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    Chapter 4 Lethality of Taurine and Alcohol Coadministration in Mice
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    Chapter 5 The effect of long-term taurine supplementation and fructose feeding on glucose and lipid homeostasis in wistar rats.
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    Chapter 6 Effect of Taurine Feeding on Bone Mineral Density and Bone Markers in Rats
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    Chapter 7 The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions.
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    Chapter 8 Perinatal Taurine Imbalance Alters the Interplay of Renin–Angiotensin System and Estrogen on Glucose–Insulin Regulation in Adult Female Rats
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    Chapter 9 Reduced Placental Taurine Transporter (TauT) Activity in Pregnancies Complicated by Pre-eclampsia and Maternal Obesity.
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    Chapter 10 Taurine 8
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    Chapter 11 Positive Correlation Between Serum Taurine and Adiponectin Levels in High-Fat Diet-Induced Obesity Rats
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    Chapter 12 Relationship Among Serum Taurine, Serum Adipokines, and Body Composition During 8-Week Human Body Weight Control Program
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    Chapter 13 Dietary taurine and nutrient intake and dietary quality by alcohol consumption level in korean male college students.
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    Chapter 14 Taurine Supplementation Restores Insulin Secretion and Reduces ER Stress Markers in Protein-Malnourished Mice.
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    Chapter 15 Taurine as a Marker for the Identification of Natural Calculus Bovis and Its Substitutes
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    Chapter 16 Taurine Deficiency and MELAS Are Closely Related Syndromes
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    Chapter 17 Antioxidant and DNA Protection Effects of Taurine by Electron Spin Resonance Spectroscopy
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    Chapter 18 Additional Effects of Taurine on the Benefits of BCAA Intake for the Delayed-Onset Muscle Soreness and Muscle Damage Induced by High-Intensity Eccentric Exercise
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    Chapter 19 Taurine Enhances Anticancer Activity of Cisplatin in Human Cervical Cancer Cells
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    Chapter 20 Comparative Evaluation of the Effects of Taurine and Thiotaurine on Alterations of the Cellular Redox Status and Activities of Antioxidant and Glutathione-Related Enzymes by Acetaminophen in the Rat
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    Chapter 21 Effects of Taurine on Myocardial cGMP/cAMP Ratio, Antioxidant Ability, and Ultrastructure in Cardiac Hypertrophy Rats Induced by Isoproterenol
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    Chapter 22 Protective Effect of Taurine on Triorthocresyl Phosphate (TOCP)-Induced Cytotoxicity in C6 Glioma Cells
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    Chapter 23 The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture.
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    Chapter 24 Relationship Among Self-Reported Fatigue, Dietary Taurine Intake, and Dietary Habits in Korean College Students
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    Chapter 25 Simulative Evaluation of Taurine Against Alopecia Caused by Stress in Caenorhabditis elegans
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    Chapter 26 Protective Effect of Taurine on the Decreased Biogenic Amine Neurotransmitter Levels in the Brain of Mice Exposed to Arsenic
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    Chapter 27 Differential Regulation of TauT by Calcitriol and Retinoic Acid via VDR/RXR in LLC-PK1 and MCF-7 Cells
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    Chapter 28 Knockdown of TauT Expression Impairs Human Embryonic Kidney 293 Cell Development
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    Chapter 29 The role of taurine on skeletal muscle cell differentiation.
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    Chapter 30 Taurine and fish development: insights for the aquaculture industry.
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    Chapter 31 Effect of Dietary Taurine and Arginine Supplementation on Bone Mineral Density in Growing Female Rats
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    Chapter 32 Taurine Enhances the Sexual Response and Mating Ability in Aged Male Rats
Attention for Chapter 23: The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture.
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Chapter title
The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture.
Chapter number 23
Book title
Taurine 8
Published in
Advances in experimental medicine and biology, February 2013
DOI 10.1007/978-1-4614-6093-0_23
Pubmed ID
Book ISBNs
978-1-4614-6092-3, 978-1-4614-6093-0

Gharibani PM, Modi J, Pan C, Menzie J, Ma Z, Chen PC, Tao R, Prentice H, Wu JY, Payam Mohammad Gharibani, Jigar Modi, Chunliu Pan, Janet Menzie, Zhiyuan Ma, Po-Chih Chen, Rui Tao, Howard Prentice, Jang-Yen Wu, Gharibani, Payam Mohammad, Modi, Jigar, Pan, Chunliu, Menzie, Janet, Ma, Zhiyuan, Chen, Po-Chih, Tao, Rui, Prentice, Howard, Wu, Jang-Yen


Taurine is an inhibitory neurotransmitter and is one of the most abundant amino acids present in the mammalian nervous system. Taurine has been shown to provide protection against neurological diseases, such as Huntington's disease, Alzheimer's disease, and stroke. Ischemic stroke is one of the leading causes of death and disability in the world. It is generally believed that ischemia-induced brain injury is largely due to excessive release of glutamate resulting in excitotoxicity and cell death. Despite extensive research, there are still no effective interventions for stroke. Recently, we have shown that taurine can provide effective protection against endoplasmic reticulum (ER) stress induced by excitotoxicity or oxidative stress in PC12 cell line or primary neuronal cell cultures. In this study, we employed hypoxia/reoxygenation conditions for primary cortical neuronal cell cultures as an in vitro model of stroke as well as the in vivo model of rat focal middle cerebral artery occlusion (MCAO). Our data showed that when primary neuronal cultures were first subjected to hypoxic conditions (0.3%, 24 h) followed by reoxygenation (21%, 24-48 h), the cell viability was greatly reduced. In the animal model of stroke (MCAO), we found that 2 h ischemia followed by 4 days reperfusion resulted in an infarct of 47.42 ± 9.86% in sections 6 mm from the frontal pole. Using taurine greatly increased cell viability in primary neuronal cell culture and decreased the infarct area of sections at 6 mm to 26.76 ± 6.91% in the MCAO model. Furthermore, levels of the ER stress protein markers GRP78, caspase-12, CHOP, and p-IRE-1 which were markedly increased in both the in vitro and in vivo models significantly declined after taurine administration, suggesting that taurine may exert neuroprotection functions in both models. Moreover, taurine could downregulate the ratio of cleaved ATF6 and full-length ATF6 in both models. In the animal model of stroke, taurine induced an upregulation of the Bcl-2/Bax ratio and downregulation of caspase-3 protein activity indicating that it attenuates apoptosis in the core of the ischemic infarct. Our results show not only taurine elicits neuroprotection through the activation of the ATF6 and the IRE1 pathways, but also it can reduce apoptosis in these models.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Researcher 9 19%
Student > Bachelor 5 10%
Student > Doctoral Student 3 6%
Student > Master 3 6%
Other 6 13%
Unknown 13 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 21%
Medicine and Dentistry 9 19%
Neuroscience 7 15%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Sports and Recreations 1 2%
Other 3 6%
Unknown 17 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2013.
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