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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis
|
|---|---|
| Published in |
PLOS ONE, March 2014
|
| DOI | 10.1371/journal.pone.0091815 |
| Pubmed ID | |
| Authors |
Duncan B. Wormer, Kevin A. Davis, James H. Henderson, Christopher E. Turner |
| Abstract |
Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in a process known as durotaxis. Durotaxis plays an important role in normal development and disease progression, including tumor invasion and metastasis. However, the signaling mechanisms underlying focal adhesion-mediated rigidity sensing and durotaxis are poorly understood. Utilizing matrix-coated polydimethylsiloxane gels to manipulate substrate compliance, we show that cdGAP, an adhesion-localized Rac1 and Cdc42 specific GTPase activating protein, is necessary for U2OS osteosarcoma cells to coordinate cell shape changes and migration as a function of extracellular matrix stiffness. CdGAP regulated rigidity-dependent motility by controlling membrane protrusion and adhesion dynamics, as well as by modulating Rac1 activity. CdGAP was also found to be necessary for U2OS cell durotaxis. Taken together, these data identify cdGAP as an important component of an integrin-mediated signaling pathway that senses and responds to mechanical cues in the extracellular matrix in order to coordinate directed cell motility. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| United States | 2 | 3% |
| Netherlands | 1 | 2% |
| Germany | 1 | 2% |
| Spain | 1 | 2% |
| Malaysia | 1 | 2% |
| Unknown | 54 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 24% |
| Researcher | 11 | 18% |
| Professor > Associate Professor | 6 | 10% |
| Student > Bachelor | 5 | 8% |
| Student > Postgraduate | 4 | 6% |
| Other | 13 | 21% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 26% |
| Biochemistry, Genetics and Molecular Biology | 13 | 21% |
| Engineering | 9 | 15% |
| Medicine and Dentistry | 3 | 5% |
| Physics and Astronomy | 3 | 5% |
| Other | 8 | 13% |
| Unknown | 10 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2014.
All research outputs
#14,192,580
of 22,749,166 outputs
Outputs from PLOS ONE
#116,125
of 194,169 outputs
Outputs of similar age
#117,684
of 220,990 outputs
Outputs of similar age from PLOS ONE
#3,187
of 5,678 outputs
Altmetric has tracked 22,749,166 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,169 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 220,990 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,678 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.