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The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111

Overview of attention for article published in PLOS ONE, March 2014
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Title
The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111
Published in
PLOS ONE, March 2014
DOI 10.1371/journal.pone.0092920
Pubmed ID
Authors

Claudio Aguilar, Nadine Schmid, Martina Lardi, Gabriella Pessi, Leo Eberl

Abstract

In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify BapR, a protein from the IclR family of transcriptional regulators that, in conjunction with QS, controls biofilm formation by affecting the expression of bapA. We present evidence that, in addition to bapA, BapR influences the expression of extracellular proteases, swimming motility and has a profound impact in the incidence of persister cells, making this regulator an interesting target for persister cells and biofilm eradication.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
United States 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 31%
Researcher 7 20%
Student > Bachelor 5 14%
Student > Doctoral Student 4 11%
Other 1 3%
Other 2 6%
Unknown 5 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 40%
Biochemistry, Genetics and Molecular Biology 7 20%
Immunology and Microbiology 3 9%
Social Sciences 2 6%
Sports and Recreations 1 3%
Other 0 0%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2014.
All research outputs
#20,224,618
of 22,749,166 outputs
Outputs from PLOS ONE
#173,308
of 194,169 outputs
Outputs of similar age
#191,378
of 223,393 outputs
Outputs of similar age from PLOS ONE
#4,709
of 5,398 outputs
Altmetric has tracked 22,749,166 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,169 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,393 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,398 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.