Title |
Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO)
|
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Published in |
Pediatric Rheumatology, December 2013
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DOI | 10.1186/1546-0096-11-47 |
Pubmed ID | |
Authors |
Christian M Hedrich, Sigrun R Hofmann, Jessica Pablik, Henner Morbach, Hermann J Girschick |
Abstract |
Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO). Autoinflammatory osteopathies are the result of a dysregulated innate immune system, resulting in immune cell infiltration of the bone and subsequent osteoclast differentiation and activation. Interestingly, autoinflammatory bone disorders are associated with inflammation of the skin and/or the intestine. In several monogenic autoinflammatory bone disorders mutations in disease-causing genes have been reported. However, regardless of recent developments, the molecular pathogenesis of CNO/CRMO remains unclear.Here, we discuss the clinical presentation and molecular pathophysiology of human autoinflammatory osteopathies and animal models with special focus on CNO/CRMO. Treatment options in monogenic autoinflammatory bone disorders and CRMO will be illustrated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Singapore | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 3% |
Spain | 2 | 2% |
Canada | 1 | <1% |
Egypt | 1 | <1% |
Unknown | 101 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 15% |
Other | 14 | 13% |
Student > Doctoral Student | 14 | 13% |
Student > Postgraduate | 12 | 11% |
Student > Ph. D. Student | 11 | 10% |
Other | 25 | 23% |
Unknown | 16 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 72 | 67% |
Immunology and Microbiology | 4 | 4% |
Agricultural and Biological Sciences | 4 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | <1% |
Other | 4 | 4% |
Unknown | 20 | 19% |