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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Discovery of the Elusive Leptin in Birds: Identification of Several ‘Missing Links’ in the Evolution of Leptin and Its Receptor
|
|---|---|
| Published in |
PLOS ONE, March 2014
|
| DOI | 10.1371/journal.pone.0092751 |
| Pubmed ID | |
| Authors |
Jeremy W. Prokop, Cameron Schmidt, Donald Gasper, Robert J. Duff, Amy Milsted, Takeshi Ohkubo, Hope C. Ball, Matthew D. Shawkey, Herman L. Mays, Larry A. Cogburn, Richard L. Londraville |
| Abstract |
Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals. While many leptin orthologs have been identified among vertebrates, an authentic leptin in birds has remained elusive and controversial. Here we identify leptin sequence from the Peregrine falcon, Falco peregrinus (pfleptin), and identify sequences from two other birds (mallard and zebra finch), and 'missing' vertebrates (elephant shark, alligator, Indian python, Chinese soft-shelled turtle, and coelacanth). The pattern of genes surrounding leptin (snd1, rbm28) is syntenic between the falcon and mammalian genomes. Phylogenetic analysis of all known leptin protein sequences improves our understanding of leptin's evolution. Structural modeling of leptin orthologs highlights a highly conserved hydrophobic core in the four-helix cytokine packing domain. A docked model of leptin with the leptin receptor for Peregrine falcon reveals several conserved amino acids important for the interaction and possible coevolution of leptin with its receptor. We also show for the first time, an authentic avian leptin sequence that activates the JAK-STAT signaling pathway. These newly identified sequences, structures, and tools for avian leptin and its receptor will allow elucidation of the function of these proteins in feral and domestic birds. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 29% |
| United Kingdom | 3 | 14% |
| Israel | 1 | 5% |
| Belgium | 1 | 5% |
| France | 1 | 5% |
| Australia | 1 | 5% |
| Thailand | 1 | 5% |
| Unknown | 7 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 81% |
| Scientists | 4 | 19% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 65 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 23% |
| Student > Bachelor | 11 | 17% |
| Researcher | 8 | 12% |
| Student > Master | 8 | 12% |
| Student > Doctoral Student | 5 | 8% |
| Other | 12 | 18% |
| Unknown | 7 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 56% |
| Biochemistry, Genetics and Molecular Biology | 10 | 15% |
| Neuroscience | 3 | 5% |
| Nursing and Health Professions | 1 | 2% |
| Chemical Engineering | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 9 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 102. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2014.
All research outputs
#389,494
of 24,417,958 outputs
Outputs from PLOS ONE
#5,562
of 210,664 outputs
Outputs of similar age
#3,385
of 228,429 outputs
Outputs of similar age from PLOS ONE
#164
of 5,345 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 210,664 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,429 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 5,345 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.