https://t.co/zCTtuLG8FT "If this view is correct, in the presence of APX a higher number of endothelial PAR2 stimulates eNOS to produce NO, which partially inhibit vasoconstrictor responses to agonists in isolated arteries."
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3,520 followers
https://t.co/zCTtuLG8FT "Our main working hypothesis is that APX, by inhibiting FXa reduces the cleavage of the PAR2 tethered ligand and the downstream signaling events responsible for PAR2 down regulation."
3,520 followers
https://t.co/zCTtuLG8FT "besides its role in the coagulation cascade, FXa is able to activate PAR2 receptors, which are expressed in a number of cell types, including endothelial cells and VSMC."
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RT @renesugar: https://t.co/zCTtuLXbHT "both thrombin and FXa are able to elicit a number of responses in vascular endothelium, like shape…