Apixaban Enhances Vasodilatation Mediated by Protease-Activated Receptor 2 in Isolated Rat Arteries

https://t.co/zCTtuLG8FT "If this view is correct, in the presence of APX a higher number of endothelial PAR2 stimulates eNOS to produce NO, which partially inhibit vasoconstrictor responses to agonists in isolated arteries."

https://t.co/zCTtuLG8FT "Our main working hypothesis is that APX, by inhibiting FXa reduces the cleavage of the PAR2 tethered ligand and the downstream signaling events responsible for PAR2 down regulation."

https://t.co/zCTtuLG8FT "besides its role in the coagulation cascade, FXa is able to activate PAR2 receptors, which are expressed in a number of cell types, including endothelial cells and VSMC."

RT @renesugar: https://t.co/zCTtuLXbHT "both thrombin and FXa are able to elicit a number of responses in vascular endothelium, like shape…