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Impact of pharmacy channel on adherence to oral oncolytics

Overview of attention for article published in BMC Health Services Research, June 2017
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Title
Impact of pharmacy channel on adherence to oral oncolytics
Published in
BMC Health Services Research, June 2017
DOI 10.1186/s12913-017-2373-2
Pubmed ID
Authors

Michael Stokes, Carolina Reyes, Yu Xia, Veronica Alas, Hans-Peter Goertz, Luke Boulanger

Abstract

Oral chemotherapy is increasingly prescribed to treat cancer. Despite its benefits, concerns have been raised regarding adherence to therapy. The study objective was to compare and measure adherence, persistence, and abandonment in patients filling prescriptions in traditional retail (TR) versus specialty pharmacy (SP) channels. Using a retrospective cohort design, we selected newly treated patients aged ≥18 years with a prescription for erlotinib, capecitabine, or imatinib during 2007-2011 from a Medco population of both United States commercial and Medicare health plans. Patients were classified according to pharmacy channel providing the medication. Abandonment was defined as a reversal following initial approval of the index prescription claim with no additional paid claims for agent within 90 days of reversal. Patients were considered adherent if the proportion of days covered between the date of the first and last oral prescription was ≥80%. In our retrospective cohort, 11,972 filled their prescriptions within the SP channel, and 30,394 filled their prescriptions within the TR channels, respectively. The SP channel had the highest proportion of adherent patients compared with TR (71.6% vs. 56.4%, P < .001). Abandonment of the initial prescription was low with overall rates of only 1.7%. In multivariate models controlling for demographic characteristics, index oncolytic, days of supply, and copay, SP channel (relative to TR) was significantly associated with lower rates of abandonment and increased adherence. Pharmacy channel may be influential on abandonment and adherence. Lower rates of abandonment and higher rates of adherence were observed among SP patients versus TR.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Student > Bachelor 3 10%
Student > Ph. D. Student 3 10%
Other 2 7%
Professor 1 3%
Other 3 10%
Unknown 12 41%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 24%
Nursing and Health Professions 3 10%
Medicine and Dentistry 3 10%
Immunology and Microbiology 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 7%
Unknown 12 41%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2017.
All research outputs
#9,328,545
of 11,667,520 outputs
Outputs from BMC Health Services Research
#3,119
of 3,766 outputs
Outputs of similar age
#193,728
of 265,431 outputs
Outputs of similar age from BMC Health Services Research
#107
of 120 outputs
Altmetric has tracked 11,667,520 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,766 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.