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N-Linked Glycosylation of the p24 Family Protein p24δ5 Modulates Retrograde Golgi-to-ER Transport of K/HDEL Ligands in Arabidopsis

Overview of attention for article published in Molecular Plant, August 2017
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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7 tweeters

Citations

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2 Dimensions

Readers on

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20 Mendeley
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Title
N-Linked Glycosylation of the p24 Family Protein p24δ5 Modulates Retrograde Golgi-to-ER Transport of K/HDEL Ligands in Arabidopsis
Published in
Molecular Plant, August 2017
DOI 10.1016/j.molp.2017.07.007
Pubmed ID
Authors

Noelia Pastor-Cantizano, María Jesús García-Murria, Cesar Bernat-Silvestre, María Jesús Marcote, Ismael Mingarro, Fernando Aniento

Abstract

The K/HDEL receptor ERD2 mediates the transport of soluble endoplasmic reticulum (ER) resident proteins containing a C-terminal K/HDEL signal from the Golgi apparatus back to the ER via COPI (COat Protein I)-coated vesicles. Sorting of ERD2 within COPI vesicles is facilitated by p24 proteins. In particular, Arabidopsis p24δ5 has been shown to interact directly with ERD2 (via its luminal GOLD -GOLgi Dynamics- domain) and with COPI proteins (via its cytoplasmic C-terminal tail) at the acidic pH of the Golgi apparatus. Several members of the p24 family in mammals and yeast have been shown to be glycosylated, but there was no previous report on glycosylation of Arabidopsis p24 proteins and on the role of the sugar moiety in p24 function. Here we show that the Arabidopsis p24 protein p24δ5 is N-glycosylated in its GOLD domain. In addition, we show that this post-translational modification is important for its coupled transport with p24β2 at the ER-Golgi interface, for its interaction with the K/HDEL receptor ERD2 and for retrograde transport of ERD2 and K/HDEL ligands from the Golgi apparatus back to the ER.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 50%
Student > Master 3 15%
Professor 2 10%
Other 1 5%
Student > Bachelor 1 5%
Other 2 10%
Unknown 1 5%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 50%
Agricultural and Biological Sciences 8 40%
Computer Science 1 5%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2017.
All research outputs
#5,169,102
of 17,635,820 outputs
Outputs from Molecular Plant
#411
of 1,193 outputs
Outputs of similar age
#91,011
of 276,369 outputs
Outputs of similar age from Molecular Plant
#16
of 30 outputs
Altmetric has tracked 17,635,820 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,193 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,369 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.