Title |
Is polymyxin B-immobilized fiber column ineffective for septic shock? A discussion on the press release for EUPHRATES trial
|
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Published in |
Journal of Intensive Care, July 2017
|
DOI | 10.1186/s40560-017-0236-x |
Pubmed ID | |
Authors |
Toshiaki Iba, Lucy Fowler |
Abstract |
The efficacy of polymyxin B-immobilized (PMX) fiber column on septic shock is still under debate. Recently, the result from "Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock (EUPHRATES)" trial has been announced as a press release. According to that report, less than a 5% mortality difference was recognized in the "per protocol population" (n = 244, 31.9 vs. 36.9%) and the decrease was not statistically significant. However, among the patients in refractory shock with a multiple organ dysfunction score of more than 9 and an EAA between 0.6 and 0.9, a 10.7% reduction in 28-day mortality was recognized (p = 0.0474) when they received two sessions of hemoperfusion using the PMX fiber column. Since this favorable effect was obtained from "post hoc" analysis, further study is expected. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 21% |
Other | 4 | 14% |
Student > Postgraduate | 3 | 10% |
Professor > Associate Professor | 3 | 10% |
Student > Master | 2 | 7% |
Other | 4 | 14% |
Unknown | 7 | 24% |
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Medicine and Dentistry | 18 | 62% |
Chemical Engineering | 1 | 3% |
Environmental Science | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Unknown | 8 | 28% |