Title |
Long noncoding RNAs, emerging players in muscle differentiation and disease
|
---|---|
Published in |
Skeletal Muscle, March 2014
|
DOI | 10.1186/2044-5040-4-8 |
Pubmed ID | |
Authors |
Maria Victoria Neguembor, Mathivanan Jothi, Davide Gabellini |
Abstract |
The vast majority of the mammalian genome is transcribed giving rise to many different types of noncoding RNAs. Among them, long noncoding RNAs are the most numerous and functionally versatile class. Indeed, the lncRNA repertoire might be as rich as the proteome. LncRNAs have emerged as key regulators of gene expression at multiple levels. They play important roles in the regulation of development, differentiation and maintenance of cell identity and they also contribute to disease. In this review, we present recent advances in the biology of lncRNAs in muscle development and differentiation. We will also discuss the contribution of lncRNAs to muscle disease with a particular focus on Duchenne and facioscapulohumeral muscular dystrophies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Norway | 1 | 25% |
France | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
Brazil | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
Unknown | 151 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 38 | 24% |
Student > Ph. D. Student | 34 | 22% |
Student > Master | 15 | 10% |
Student > Bachelor | 13 | 8% |
Professor | 10 | 6% |
Other | 21 | 13% |
Unknown | 26 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 56 | 36% |
Biochemistry, Genetics and Molecular Biology | 51 | 32% |
Medicine and Dentistry | 7 | 4% |
Neuroscience | 3 | 2% |
Sports and Recreations | 2 | 1% |
Other | 6 | 4% |
Unknown | 32 | 20% |