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Mendeley readers
Attention Score in Context
| Title |
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population
|
|---|---|
| Published in |
Nature Genetics, June 2011
|
| DOI | 10.1038/ng.851 |
| Pubmed ID | |
| Authors |
Liang-Dan Sun, Feng-Li Xiao, Yang Li, Wen-Ming Zhou, Hua-Yang Tang, Xian-Fa Tang, Hui Zhang, Heidi Schaarschmidt, Xian-Bo Zuo, Regina Foelster-Holst, Su-Min He, Mei Shi, Qiang Liu, Yong-Mei Lv, Xi-Lan Chen, Kun-Ju Zhu, Yi-Feng Guo, Da-Yan Hu, Ming Li, Min Li, Yan-Hong Zhang, Xin Zhang, Jian-Ping Tang, Bi-Rong Guo, Hua Wang, Yuan Liu, Xiao-Yan Zou, Fu-Sheng Zhou, Xiao-Yan Liu, Gang Chen, Lin Ma, Shu-Mei Zhang, Ai-Ping Jiang, Xiao-Dong Zheng, Xing-Hua Gao, Pan Li, Cai-Xia Tu, Xian-Yong Yin, Xiu-Ping Han, Yun-Qing Ren, Shun-Peng Song, Zhi-Yong Lu, Xing-Lian Zhang, Yong Cui, Jing Chang, Min Gao, Xiao-Yan Luo, Pei-Guang Wang, Xing Dai, Wei Su, Hui Li, Chun-Pin Shen, Sheng-Xiu Liu, Xiao-Bo Feng, Chun-Jun Yang, Guo-Shu Lin, Zai-Xing Wang, Jian-Qing Huang, Xing Fan, Yan Wang, Yi-Xiao Bao, Sen Yang, Jian-Jun Liu, Andre Franke, Stephan Weidinger, Zhi-Rong Yao, Xue-Jun Zhang |
| Abstract |
Atopic dermatitis is a chronic, relapsing form of inflammatory skin disorder that is affected by genetic and environmental factors. We performed a genome-wide association study of atopic dermatitis in a Chinese Han population using 1,012 affected individuals (cases) and 1,362 controls followed by a replication study in an additional 3,624 cases and 12,197 controls of Chinese Han ethnicity, as well as 1,806 cases and 3,256 controls from Germany. We identified previously undescribed susceptibility loci at 5q22.1 (TMEM232 and SLC25A46, rs7701890, P(combined) = 3.15 × 10(-9), odds ratio (OR) = 1.24) and 20q13.33 (TNFRSF6B and ZGPAT, rs6010620, P(combined) = 3.0 × 10(-8), OR = 1.17) and replicated another previously reported locus at 1q21.3 (FLG, rs3126085, P(combined) = 5.90 × 10(-12), OR = 0.82) in the Chinese sample. The 20q13.33 locus also showed evidence for association in the German sample (rs6010620, P = 2.87 × 10(-5), OR = 1.25). Our study identifies new genetic susceptibility factors and suggests previously unidentified biological pathways in atopic dermatitis. |
Mendeley readers
The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| Germany | 2 | 1% |
| Japan | 1 | <1% |
| Unknown | 148 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 40 | 26% |
| Student > Ph. D. Student | 27 | 18% |
| Student > Master | 13 | 8% |
| Student > Doctoral Student | 9 | 6% |
| Student > Bachelor | 8 | 5% |
| Other | 29 | 19% |
| Unknown | 28 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 29% |
| Medicine and Dentistry | 27 | 18% |
| Biochemistry, Genetics and Molecular Biology | 18 | 12% |
| Immunology and Microbiology | 6 | 4% |
| Nursing and Health Professions | 5 | 3% |
| Other | 15 | 10% |
| Unknown | 39 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2012.
All research outputs
#3,170,872
of 22,649,029 outputs
Outputs from Nature Genetics
#3,378
of 7,172 outputs
Outputs of similar age
#15,933
of 113,232 outputs
Outputs of similar age from Nature Genetics
#25
of 58 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,172 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.9. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 113,232 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.