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The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia

Overview of attention for article published in Revista Brasileira de Hematologia e Hemoterapia, January 2011
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Title
The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia
Published in
Revista Brasileira de Hematologia e Hemoterapia, January 2011
DOI 10.5581/1516-8484.20110054
Pubmed ID
Authors

Ana Paula Alegretti, Christina Matzenbacher Bittar, Rosane Bittencourt, Amanda Kirchner Piccoli, Laiana Schneider, Lúcia Mariano Silla, Suzane Dal Bó, Ricardo Machado Xavier

Abstract

The expression of CD56 is considered a bad prognostic factor for overall survival, lower rates or short complete remission and extramedullary invasion but the results are controversial. The importance of validating new prognostic parameters in acute leukemias was the reason to investigate the CD56 expression in blast cells of patients with acute myeloid leukemia. A cohort of 48 patients treated at Hospital de Clinicas de Porto Alegre and diagnosed with acute myeloid leukemia as classified by the French-American-British group (FAB) criteria using cell morphology, cytochemistry and flow cytometry were evaluated. Eight cases (16.7%) were CD56 positive without correlation to age or gender. The highest incidence of CD56 positivity was in FAB subtypes M4 and M5. The death rate during induction was not significantly different between patients with and without CD56 expression (62.5% vs. 27.5%; p-value = 0.097). However, patients that expressed CD56 had significantly lower overall survival than those who did not (mean 4.0 months vs. 14.5 months; p-value = 0.03). The data suggest that expression of CD56 in acute myeloid leukemia may be indicative of poor prognosis because it is associated with a shorter overall survival. The death rate during induction was not significantly different despite an apparent difference in proportions between groups.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 18%
Student > Bachelor 4 14%
Researcher 4 14%
Student > Postgraduate 3 11%
Student > Master 3 11%
Other 4 14%
Unknown 5 18%
Readers by discipline Count As %
Medicine and Dentistry 13 46%
Biochemistry, Genetics and Molecular Biology 5 18%
Agricultural and Biological Sciences 2 7%
Immunology and Microbiology 2 7%
Computer Science 1 4%
Other 0 0%
Unknown 5 18%