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Mendeley readers
Attention Score in Context
| Title |
Multiple myeloma with deletion of chromosome 13q is characterized by increased bone marrow neovascularization
|
|---|---|
| Published in |
British Journal of Haematology, December 2001
|
| DOI | 10.1046/j.1365-2141.2000.02248.x |
| Pubmed ID | |
| Authors |
Susanne Schreiber, Jutta Ackermann, Andreas Obermair, Hannes Kaufmann, Eleonora Urbauer, Katharina Aletaha, Heinz Gisslinger, Andreas Chott, Heinz Huber, Johannes Drach |
| Abstract |
Anti-angiogenesis therapy with thalidomide has been reported to have marked activity in multiple myeloma (MM). As cytogenetics is an independent prognostic factor in MM, we analysed bone marrow (BM) angiogenesis and cytogenetic abnormalities in 34 patients with active MM. BM microvessel density (MVD), as determined by staining with anti-CD34, was significantly higher in MM (MVD: 221 +/- 94 per mm2) than in controls (80 +/- 36; P < 0.0001). In patients with the presence of at least one unfavourable cytogenetic abnormality (deletion of 13q14, deletion of 17p13, aberrations of 11q), a significantly increased BM MVD was observed (254 +/- 93 vs. 160 +/- 60 in patients with absence of these abnormalities; P = 0.0035). Further analyses indicated that increased BM MVD was significantly correlated with deletion of 13q14 (259 +/- 96 vs. 188 +/- 80; P = 0. 026), but not with other cytogenetic, clinical and laboratory MM parameters. We conclude that BM neovascularization is particularly high in MM with deletion of 13q14, which provides a rationale for use of anti-angiogenic strategies in the treatment of MM with high-risk cytogenetics. |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 27% |
| Researcher | 3 | 20% |
| Other | 2 | 13% |
| Student > Postgraduate | 2 | 13% |
| Professor | 1 | 7% |
| Other | 3 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 60% |
| Agricultural and Biological Sciences | 3 | 20% |
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Immunology and Microbiology | 1 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2010.
All research outputs
#8,248,433
of 24,704,144 outputs
Outputs from British Journal of Haematology
#3,029
of 7,974 outputs
Outputs of similar age
#32,147
of 130,628 outputs
Outputs of similar age from British Journal of Haematology
#126
of 439 outputs
Altmetric has tracked 24,704,144 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,974 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,628 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 439 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.