Title |
The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study
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Published in |
Trials, January 2014
|
DOI | 10.1186/1745-6215-15-26 |
Pubmed ID | |
Authors |
Tatsuo Hosoya, Kenjiro Kimura, Sadayoshi Itoh, Masaaki Inaba, Shunya Uchida, Yasuhiko Tomino, Hirofumi Makino, Seiichi Matsuo, Tetsuya Yamamoto, Iwao Ohno, Yugo Shibagaki, Satoshi Iimuro, Naohiko Imai, Masanari Kuwabara, Hiroshi Hayakawa |
Abstract |
Hyperuricemia is a risk factor for the onset of chronic kidney disease (CKD) and is significantly associated with the progression of CKD. However, there is no sufficient evidence by interventional research supporting a cause-effect relationship. Hyperuricemic patients without gouty arthritis, whose serum urate (SUA) concentration is ≥8.0 mg/dL and who have a complication, are treated by pharmacotherapy in addition to lifestyle guidance. Nevertheless, there is no evidence that rationalizes pharmacotherapy for patients with hyperuricemia who have no complication and whose SUA concentration is below 9.0 mg/dL. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Denmark | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 96 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 17% |
Student > Master | 13 | 13% |
Student > Bachelor | 12 | 12% |
Other | 10 | 10% |
Student > Doctoral Student | 8 | 8% |
Other | 21 | 21% |
Unknown | 18 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 42 | 42% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Social Sciences | 3 | 3% |
Sports and Recreations | 3 | 3% |
Other | 14 | 14% |
Unknown | 25 | 25% |