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Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia

Overview of attention for article published in Neuropsychopharmacology, October 2013
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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6 tweeters

Citations

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61 Dimensions

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83 Mendeley
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Title
Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia
Published in
Neuropsychopharmacology, October 2013
DOI 10.1038/npp.2013.294
Pubmed ID
Authors

Laurena Holleran, Mohamed Ahmed, Heike Anderson-Schmidt, John McFarland, Louise Emsell, Alexander Leemans, Cathy Scanlon, Peter Dockery, Peter McCarthy, Gareth J Barker, Colm McDonald, Dara M Cannon

Abstract

Diffusion MRI investigations in schizophrenia provide evidence of abnormal white matter (WM) microstructural organization as indicated by reduced fractional anisotropy (FA) primarily in interhemispheric, left frontal and temporal WM. Using tract-based spatial statistics (TBSS), we examined diffusion parameters in a sample of patients with severe chronic schizophrenia. Diffusion MRI data were acquired on 19 patients with chronic severe schizophrenia and 19 age- and gender-matched healthy controls using a 64 gradient direction sequence, (b=1300 s/mm(2)) collected on a Siemens 1.5T MRI scanner. Diagnosis of schizophrenia was determined by Diagnostic and Statistical Manual for Mental Disorders 4th Edition (DSM-IV) Structured Clinical Interview for DSM disorder (SCID). Patients were treatment resistance, having failed to respond to at least two antipsychotic medications, and had prolonged periods of moderate to severe positive or negative symptoms. Analysis of diffusion parameters was carried out using TBSS. Individuals with chronic severe schizophrenia had significantly reduced FA with corresponding increased radial diffusivity in the genu, body, and splenium of the corpus callosum, the right posterior limb of the internal capsule, right external capsule, and the right temporal inferior longitudinal fasciculus. There were no voxels of significantly increased FA in patients compared with controls. A decrease in splenium FA was shown to be related to a longer illness duration. We detected widespread abnormal diffusivity properties in the callosal and temporal lobe WM regions in individuals with severe chronic schizophrenia who have not previously been exposed to clozapine. These deficits can be driven by a number of factors that are indistinguishable using in vivo diffusion-weighted imaging, but may be related to reduced axonal number or packing density, abnormal glial cell arrangement or function, and reduced myelin.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 1%
Canada 1 1%
Unknown 81 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 16%
Student > Ph. D. Student 12 14%
Student > Bachelor 11 13%
Student > Master 8 10%
Other 7 8%
Other 17 20%
Unknown 15 18%
Readers by discipline Count As %
Psychology 15 18%
Medicine and Dentistry 15 18%
Neuroscience 12 14%
Agricultural and Biological Sciences 12 14%
Biochemistry, Genetics and Molecular Biology 3 4%
Other 5 6%
Unknown 21 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2014.
All research outputs
#5,659,407
of 18,104,217 outputs
Outputs from Neuropsychopharmacology
#2,167
of 3,483 outputs
Outputs of similar age
#61,015
of 199,994 outputs
Outputs of similar age from Neuropsychopharmacology
#19
of 44 outputs
Altmetric has tracked 18,104,217 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 3,483 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.1. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,994 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.