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Antibody reactivity against Helicobacter pylori proteins in a sample of the Spanish adult population in 2008-2013

Overview of attention for article published in Helicobacter, July 2017
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Title
Antibody reactivity against Helicobacter pylori proteins in a sample of the Spanish adult population in 2008-2013
Published in
Helicobacter, July 2017
DOI 10.1111/hel.12401
Pubmed ID
Authors

Nerea Fernández-de-Larrea, Angelika Michel, Beatriz Romero, Julia Butt, Michael Pawlita, Beatriz Pérez-Gómez, Gemma Castaño-Vinyals, Victor Moreno, Vicente Martín, Pilar Amiano, Jesús Castilla, Guillermo Fernández-Tardón, Trinidad Dierssen-Sotos, Juan Clofent, Juan Alguacil, José María Huerta, José Juan Jiménez-Moleón, Aurelio Barricarte, Amaia Molinuevo, Tania Fernández-Villa, Delphine Casabonne, Ángeles Sierra, Manolis Kogevinas, Silvia de Sanjosé, Marina Pollán, Rosa del Campo, Tim Waterboer, Nuria Aragonés

Abstract

Differences in Helicobacter pylori protein expression have been related to the risk of severe gastric diseases. In Spain, a marked geographic pattern in gastric cancer mortality has long been reported. To characterize antibody reactivity patterns against 16 H. pylori proteins, by age, sex, and region of birth, in a large sample of the Spanish adult population. Antibody reactivity was quantified by H. pylori multiplex serology in a sample from the control group of the multicase-control study MCC-Spain. For this analysis, 2555 population-based controls were included. Each participant was classified as seropositive or seronegative for each protein according to specific cutoffs. Overall H. pylori seroprevalence was defined as positivity against ≥4 proteins. Descriptive analyses by age, sex, and region of birth were performed for both seroprevalence and seroreactivity (continuous measure). Differences among groups were tested by logistic and linear regression models. Overall H. pylori seroprevalence increased with age in both sexes. For ages 55-74, seroprevalence was lower in women than in men (84% vs 92%, P<.001). Region of birth explained 7% of the variability in seroprevalence. Among H. pylori seropositive subjects, proteins with the highest seroprevalence were GroEL, NapA, HP231, and Omp. Seropositivity for most of the proteins increased or remained stable with age, rising mainly for CagA, GroEL, and HyuA in women. A clear cohort effect was not observed. This is the first study to describe the antibody patterns against 16 H. pylori proteins in the Spanish population. We found variability in the H. pylori antibody profiles according to both individual factors such as age and sex, and environmental factors such as the region of birth. The slightness of the reduction in seropositivity with decreasing age highlights the ongoing importance of this infection.

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Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 41%
Unspecified 3 14%
Student > Doctoral Student 3 14%
Other 2 9%
Professor 2 9%
Other 3 14%
Readers by discipline Count As %
Medicine and Dentistry 8 36%
Unspecified 7 32%
Biochemistry, Genetics and Molecular Biology 2 9%
Immunology and Microbiology 2 9%
Nursing and Health Professions 1 5%
Other 2 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2018.
All research outputs
#10,310,009
of 12,920,060 outputs
Outputs from Helicobacter
#305
of 438 outputs
Outputs of similar age
#193,949
of 264,099 outputs
Outputs of similar age from Helicobacter
#8
of 14 outputs
Altmetric has tracked 12,920,060 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 438 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.