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Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury

Overview of attention for article published in Journal of Neuroinflammation, April 2014
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62 Mendeley
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Title
Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury
Published in
Journal of Neuroinflammation, April 2014
DOI 10.1186/1742-2094-11-71
Pubmed ID
Authors

Zai-Wang Li, Ji-Jun Li, Lan Wang, Jian-Ping Zhang, Jing-Jing Wu, Xu-Qiang Mao, Guo-Feng Shi, Qian Wang, Feng Wang, Jian Zou

Abstract

Astrogliosis is a common phenomenon after spinal cord injury (SCI). Although this process exerts positive effects on axonal regeneration, excessive astrogliosis imparts negative effects on neuronal repair and recovery. Epidermal growth factor receptor (EGFR) pathway is critical to the regulation of reactive astrogliosis, and therefore is a potential target of therapeutics to better control the response. In this report, we aim to investigate whether blocking EGFR signaling using an EGFR tyrosine kinase specific inhibitor can attenuate reactive astrogliosis and promote functional recovery after a traumatic SCI.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 27%
Researcher 9 15%
Student > Bachelor 7 11%
Student > Doctoral Student 5 8%
Student > Master 4 6%
Other 10 16%
Unknown 10 16%
Readers by discipline Count As %
Neuroscience 13 21%
Agricultural and Biological Sciences 12 19%
Medicine and Dentistry 8 13%
Biochemistry, Genetics and Molecular Biology 3 5%
Nursing and Health Professions 3 5%
Other 7 11%
Unknown 16 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2014.
All research outputs
#15,739,529
of 25,373,627 outputs
Outputs from Journal of Neuroinflammation
#1,759
of 2,951 outputs
Outputs of similar age
#126,531
of 239,360 outputs
Outputs of similar age from Journal of Neuroinflammation
#21
of 40 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,951 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,360 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.