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Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities

Overview of attention for article published in Anais da Academia Brasileira de Ciências, July 2017
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Title
Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities
Published in
Anais da Academia Brasileira de Ciências, July 2017
DOI 10.1590/0001-3765201720160725
Pubmed ID
Authors

TÁSSIA L.A. DOS SANTOS, RAPHAEL F. QUEIROZ, ALEXANDRA C.H.F. SAWAYA, BEGOÑA GIMENEZ-CASSINA LOPEZ, MILENA B.P. SOARES, DANIEL P. BEZERRA, ANA CAROLINA B.C. RODRIGUES, VANDERLÚCIA F. DE PAULA, ANA MARIA WALDSCHMIDT

Abstract

Geopropolis is a special type of propolis produced by stingless bees. Several pharmacological properties have been described for different types of geopropolis, but there have been no previous studies of the geopropolis from Melipona mondury. In this study, we investigated the antioxidant, antibacterial, and antiproliferative activities of M. mondury geopropolis, and determined its chemical profile. The antioxidant activity was determined using in vitro ABTS·+, ·DPPH, and β-carotene/linoleic acid co-oxidation methods. The antibacterial activity was determined using a microdilution method with Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant S. aureus. The antiproliferative effect was determined in tumor cell lines using the Alamar Blue assay. The chemical profile was obtained using UHPLC-MS and UHPLC-MS/MS. The butanolic fraction had the highest concentration of phenolic compounds and more potent antioxidant properties in all assays. This fraction also had bacteriostatic and bactericidal effects against all bacterial strains at low concentrations, especially S. aureus. The hexane fraction had the highest antiproliferative potential, with IC50 values ranging from 24.2 to 46.6 µg/mL in HL-60 (human promyelocytic leukemia cell) and K562 (human chronic myelocytic leukemia cell), respectively. Preliminary chemical analysis indicates the presence of terpenes and gallic acid in the geopropolis. Our results indicate the therapeutic potential of geopropolis from M. mondury against inflammatory, oxidative, infectious, and neoplastic diseases.

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Geographical breakdown

Country Count As %
Unknown 89 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 20%
Student > Master 9 10%
Researcher 8 9%
Student > Doctoral Student 7 8%
Professor 4 4%
Other 9 10%
Unknown 34 38%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 13%
Pharmacology, Toxicology and Pharmaceutical Science 9 10%
Chemistry 7 8%
Biochemistry, Genetics and Molecular Biology 7 8%
Medicine and Dentistry 5 6%
Other 8 9%
Unknown 41 46%