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Mendeley readers
Attention Score in Context
| Title |
Cooperative tumorigenic effects of germline mutations in Rb and p53
|
|---|---|
| Published in |
Nature Genetics, August 1994
|
| DOI | 10.1038/ng0894-480 |
| Pubmed ID | |
| Authors |
Bart O. Williams, Lee Remington, Daniel M. Albert, Shizuo Mukai, Roderick T. Bronson, Tyler Jacks |
| Abstract |
The tumour suppressor genes Rb and p53 are mutated in several types of human cancer, and many tumour types carry mutations in both genes. To study how these genes normally function, we and others have created mouse strains with Rb and p53 mutations. Here we describe the phenotypic effects of combined germline mutations in these two tumour suppressor genes. Mice mutant for both genes have reduced viability and exhibit novel pathology including pinealoblastomas, islet cell tumours, bronchial epithelial hyperplasia and retinal dysplasia. These data indicate that mutations in Rb and p53 can cooperate in the transformation of certain cell types in the mouse. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 70 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 24% |
| Researcher | 13 | 18% |
| Professor | 7 | 10% |
| Student > Bachelor | 5 | 7% |
| Student > Postgraduate | 3 | 4% |
| Other | 12 | 17% |
| Unknown | 14 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 32% |
| Biochemistry, Genetics and Molecular Biology | 16 | 23% |
| Medicine and Dentistry | 11 | 15% |
| Unspecified | 2 | 3% |
| Mathematics | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 16 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2015.
All research outputs
#2,487,668
of 22,994,508 outputs
Outputs from Nature Genetics
#2,967
of 7,222 outputs
Outputs of similar age
#738
of 21,952 outputs
Outputs of similar age from Nature Genetics
#5
of 44 outputs
Altmetric has tracked 22,994,508 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,222 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 21,952 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.