Title |
Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice
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Published in |
Brazilian Journal of Medical and Biological Research, October 2015
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DOI | 10.1590/1414-431x20154506 |
Pubmed ID | |
Authors |
F.N. Carlesso, L.L. Fuscaldi, R.S. Araújo, C.S. Teixeira, M.C. Oliveira, S.O.A. Fernandes, G.D. Cassali, D.C. Reis, A.L.B. Barros, V.N. Cardoso |
Abstract |
Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic cancer cells. Thus, a radiolabeled peptide derivative of gastrin-releasing peptide (GRP) may be useful as a specific imaging probe. The purpose of the present study was to evaluate the feasibility of using99mTc-HYNIC-βAla-Bombesin(7-14)as an imaging probe for Capan-1 pancreatic adenocarcinoma. Xenographic pancreatic tumor was developed in nude mice and characterized by histopathological analysis. Biodistribution studies and scintigraphic images were carried out in tumor-bearing nude mice. The two methods showed higher uptake by pancreatic tumor when compared to muscle (used as control), and the tumor-to-muscle ratio indicated that99mTc-HYNIC-βAla-Bombesin(7-14)uptake was four-fold higher in tumor cells than in other tissues. Scintigraphic images also showed a clear signal at the tumor site. The present data indicate that99mTc-HYNIC-βAla-Bombesin(7-14)may be useful for the detection of pancreatic adenocarcinoma. |
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Geographical breakdown
Country | Count | As % |
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Demographic breakdown
Readers by professional status | Count | As % |
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Other | 3 | 25% |
Student > Doctoral Student | 2 | 17% |
Student > Master | 2 | 17% |
Student > Bachelor | 1 | 8% |
Student > Ph. D. Student | 1 | 8% |
Other | 3 | 25% |
Readers by discipline | Count | As % |
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Chemistry | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |