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Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, October 2015
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Title
Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice
Published in
Brazilian Journal of Medical and Biological Research, October 2015
DOI 10.1590/1414-431x20154506
Pubmed ID
Authors

F.N. Carlesso, L.L. Fuscaldi, R.S. Araújo, C.S. Teixeira, M.C. Oliveira, S.O.A. Fernandes, G.D. Cassali, D.C. Reis, A.L.B. Barros, V.N. Cardoso

Abstract

Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic cancer cells. Thus, a radiolabeled peptide derivative of gastrin-releasing peptide (GRP) may be useful as a specific imaging probe. The purpose of the present study was to evaluate the feasibility of using99mTc-HYNIC-βAla-Bombesin(7-14)as an imaging probe for Capan-1 pancreatic adenocarcinoma. Xenographic pancreatic tumor was developed in nude mice and characterized by histopathological analysis. Biodistribution studies and scintigraphic images were carried out in tumor-bearing nude mice. The two methods showed higher uptake by pancreatic tumor when compared to muscle (used as control), and the tumor-to-muscle ratio indicated that99mTc-HYNIC-βAla-Bombesin(7-14)uptake was four-fold higher in tumor cells than in other tissues. Scintigraphic images also showed a clear signal at the tumor site. The present data indicate that99mTc-HYNIC-βAla-Bombesin(7-14)may be useful for the detection of pancreatic adenocarcinoma.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 18%
Student > Doctoral Student 2 18%
Student > Master 2 18%
Student > Bachelor 1 9%
Student > Ph. D. Student 1 9%
Other 3 27%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 18%
Medicine and Dentistry 2 18%
Psychology 1 9%
Biochemistry, Genetics and Molecular Biology 1 9%
Chemistry 1 9%
Other 1 9%
Unknown 3 27%