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A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages

Overview of attention for article published in BMC Microbiology, January 2014
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1 tweeter

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Title
A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages
Published in
BMC Microbiology, January 2014
DOI 10.1186/1471-2180-14-98
Pubmed ID
Authors

Gianluca Pegoraro, Brett P Eaton, Ricky L Ulrich, Douglas J Lane, Jenifer F Ojeda, Sina Bavari, David DeShazer, Rekha G Panchal

Abstract

Burkholderia pseudomallei (Bp), a Gram-negative, motile, facultative intracellular bacterium is the causative agent of melioidosis in humans and animals. The Bp genome encodes a repertoire of virulence factors, including the cluster 3 type III secretion system (T3SS-3), the cluster 1 type VI secretion system (T6SS-1), and the intracellular motility protein BimA, that enable the pathogen to invade both phagocytic and non-phagocytic cells. A unique hallmark of Bp infection both in vitro and in vivo is its ability to induce cell-to-cell fusion of macrophages to form multinucleated giant cells (MNGCs), which to date are semi-quantitatively reported following visual inspection.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 28%
Student > Master 6 19%
Student > Bachelor 5 16%
Other 5 16%
Student > Doctoral Student 4 13%
Other 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 41%
Biochemistry, Genetics and Molecular Biology 6 19%
Immunology and Microbiology 4 13%
Medicine and Dentistry 2 6%
Unspecified 2 6%
Other 5 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2014.
All research outputs
#2,051,974
of 3,686,760 outputs
Outputs from BMC Microbiology
#391
of 747 outputs
Outputs of similar age
#48,877
of 94,154 outputs
Outputs of similar age from BMC Microbiology
#26
of 52 outputs
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So far Altmetric has tracked 747 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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