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Strong HIV-1-Specific T Cell Responses in HIV-1-Exposed Uninfected Infants and Neonates Revealed after Regulatory T Cell Removal

Overview of attention for article published in PLOS ONE, December 2006
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

patent
1 patent
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1 research highlight platform

Readers on

mendeley
96 Mendeley
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3 Connotea
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Title
Strong HIV-1-Specific T Cell Responses in HIV-1-Exposed Uninfected Infants and Neonates Revealed after Regulatory T Cell Removal
Published in
PLOS ONE, December 2006
DOI 10.1371/journal.pone.0000102
Pubmed ID
Authors

Fatema A. Legrand, Douglas F. Nixon, Christopher P. Loo, Erika Ono, Joan M. Chapman, Maristela Miyamoto, Ricardo S. Diaz, Amélia M.N. Santos, Regina C.M. Succi, Jacob Abadi, Michael G. Rosenberg, Maria Isabel de Moraes-Pinto, Esper G. Kallas

Abstract

In utero transmission of HIV-1 occurs on average in only 3%-15% of HIV-1-exposed neonates born to mothers not on antiretroviral drug therapy. Thus, despite potential exposure, the majority of infants remain uninfected. Weak HIV-1-specific T-cell responses have been detected in children exposed to HIV-1, and potentially contribute to protection against infection. We, and others, have recently shown that the removal of CD4(+) CD25(+) T-regulatory (Treg) cells can reveal strong HIV-1 specific T-cell responses in some HIV-1 infected adults. Here, we hypothesized that Treg cells could suppress HIV-1-specific immune responses in young children.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Belgium 1 1%
South Africa 1 1%
Brazil 1 1%
Unknown 92 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 20%
Student > Postgraduate 12 13%
Researcher 11 11%
Student > Master 9 9%
Professor 8 8%
Other 20 21%
Unknown 17 18%
Readers by discipline Count As %
Medicine and Dentistry 27 28%
Agricultural and Biological Sciences 24 25%
Immunology and Microbiology 12 13%
Biochemistry, Genetics and Molecular Biology 6 6%
Business, Management and Accounting 3 3%
Other 6 6%
Unknown 18 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2013.
All research outputs
#6,373,258
of 22,649,029 outputs
Outputs from PLOS ONE
#76,229
of 193,361 outputs
Outputs of similar age
#34,745
of 156,025 outputs
Outputs of similar age from PLOS ONE
#95
of 127 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 193,361 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,025 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.