Title |
Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer
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Published in |
BMC Cancer, April 2014
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DOI | 10.1186/1471-2407-14-303 |
Pubmed ID | |
Authors |
Salvatore Micali, Stefania Bulotta, Cinzia Puppin, Angelo Territo, Michele Navarra, Giampaolo Bianchi, Giuseppe Damante, Sebastiano Filetti, Diego Russo |
Abstract |
Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia. Discovery of NIS expression in extrathyroidal tissues, including transformed cells, has opened a novel field of research regarding NIS-expressing extrathyroidal neoplasia. Indeed, expression of NIS may be used as a biomarker for diagnostic, prognostic, and therapeutic purposes. Moreover, stimulation of endogenous NIS expression may permit the radioiodine treatment of extrathyroidal lesions by concentrating this radioisotope. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 2% |
Unknown | 54 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 16% |
Student > Bachelor | 8 | 15% |
Student > Ph. D. Student | 7 | 13% |
Professor | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 10 | 18% |
Unknown | 14 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 33% |
Biochemistry, Genetics and Molecular Biology | 10 | 18% |
Agricultural and Biological Sciences | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Nursing and Health Professions | 2 | 4% |
Other | 2 | 4% |
Unknown | 16 | 29% |