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Thalassemia Bone Disease: A 19-Year Longitudinal Analysis

Overview of attention for article published in Journal of Bone & Mineral Research, October 2014
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Title
Thalassemia Bone Disease: A 19-Year Longitudinal Analysis
Published in
Journal of Bone & Mineral Research, October 2014
DOI 10.1002/jbmr.2266
Pubmed ID
Authors

Phillip Wong, Peter J Fuller, Matthew T Gillespie, Vicky Kartsogiannis, Peter G Kerr, James CG Doery, Eldho Paul, Donald K Bowden, Boyd J Strauss, Frances Milat

Abstract

Thalassemia is an inherited disorder of β-globin chain synthesis leading to ineffective erythropoiesis requiring chronic transfusion therapy in its most severe form. This leads to iron overload, marrow expansion and hormonal complications which are implicated in bone deformity and loss of bone mineral density (BMD). In this 19 year retrospective longitudinal study, the relationships between BMD (determined by dual energy X-ray absorptiometry) and risk factors for osteoporosis in 277 subjects with transfusion-dependent thalassemia were examined. The mean age at first review was 23.2 ± 11.9 years and 43.7% were male. Hypogonadism was present in 28.9%. Fractures were confirmed in 11.6% of subjects and was greater in males (16.5%) compared to females (7.7%). Lumbar spine (LS), femoral neck (FN) and total body (TB) Z scores were derived. Patients with transfusion-dependent thalassemia had a significant longitudinal decline in BMD at the FN and TB. In the linear mixed model analysis of BMD and risk factors for bone loss, FN Z score was more significantly associated with risk factors compared to the LS and TB. The rate of decline at the FN was 0.02 Z score per year and was 3.85 fold greater in males. The decline in FN Z score over the last 5 years (years 15-19) was 2.5 fold that of the previous 7 years (years 8-14) and coincided with a change in iron chelator therapy from desferrioxamine over to deferasirox. Hemoglobin (Hb) levels positively correlated with higher TB and LS Z scores. In conclusion, the FN is the preferred site for follow-up of BMD. Male patients with β-thalassemia experienced a greater loss of BMD and had a higher prevalence of fractures compared to females. Transfusing patients (particularly males) to a higher Hb target may reduce the decline in BMD. Whether deferasirox is implicated in bone loss warrants further study. © 2014 American Society for Bone and Mineral Research.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 7 19%
Student > Master 7 19%
Unspecified 4 11%
Researcher 4 11%
Other 3 8%
Other 11 31%
Readers by discipline Count As %
Medicine and Dentistry 17 47%
Unspecified 6 17%
Agricultural and Biological Sciences 5 14%
Biochemistry, Genetics and Molecular Biology 2 6%
Economics, Econometrics and Finance 1 3%
Other 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2014.
All research outputs
#7,578,980
of 12,567,303 outputs
Outputs from Journal of Bone & Mineral Research
#2,556
of 3,334 outputs
Outputs of similar age
#90,515
of 189,480 outputs
Outputs of similar age from Journal of Bone & Mineral Research
#53
of 76 outputs
Altmetric has tracked 12,567,303 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,334 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,480 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.