↓ Skip to main content

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

Overview of attention for article published in Nature Medicine, May 2014
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 4,454)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Readers on

mendeley
847 Mendeley
citeulike
4 CiteULike
Title
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.
Published in
Nature Medicine, May 2014
DOI 10.1038/nm.3569
Pubmed ID
Authors

Saul A Villeda, Kristopher E Plambeck, Jinte Middeldorp, Joseph M Castellano, Kira I Mosher, Jian Luo, Lucas K Smith, Gregor Bieri, Karin Lin, Daniela Berdnik, Rafael Wabl, Joe Udeochu, Elizabeth G Wheatley, Bende Zou, Danielle A Simmons, Xinmin S Xie, Frank M Longo, Tony Wyss-Coray, Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T

Abstract

As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the effects of aging. Here we report that exposure of an aged animal to young blood can counteract and reverse pre-existing effects of brain aging at the molecular, structural, functional and cognitive level. Genome-wide microarray analysis of heterochronic parabionts--in which circulatory systems of young and aged animals are connected--identified synaptic plasticity-related transcriptional changes in the hippocampus of aged mice. Dendritic spine density of mature neurons increased and synaptic plasticity improved in the hippocampus of aged heterochronic parabionts. At the cognitive level, systemic administration of young blood plasma into aged mice improved age-related cognitive impairments in both contextual fear conditioning and spatial learning and memory. Structural and cognitive enhancements elicited by exposure to young blood are mediated, in part, by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus. Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function.

Twitter Demographics

The data shown below were collected from the profiles of 804 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 847 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 33 4%
Japan 9 1%
United Kingdom 8 <1%
Spain 7 <1%
Germany 6 <1%
Brazil 6 <1%
China 4 <1%
Canada 4 <1%
Portugal 4 <1%
Other 26 3%
Unknown 740 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 227 27%
Researcher 221 26%
Student > Bachelor 103 12%
Student > Master 91 11%
Student > Postgraduate 46 5%
Other 159 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 434 51%
Medicine and Dentistry 125 15%
Biochemistry, Genetics and Molecular Biology 88 10%
Neuroscience 69 8%
Unspecified 26 3%
Other 105 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1536. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2017.
All research outputs
#678
of 8,414,443 outputs
Outputs from Nature Medicine
#3
of 4,454 outputs
Outputs of similar age
#15
of 181,016 outputs
Outputs of similar age from Nature Medicine
#1
of 102 outputs
Altmetric has tracked 8,414,443 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,454 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 181,016 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.