| Title |
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
|
|---|---|
| Published in |
Nature Medicine, May 2014
|
| DOI | 10.1038/nm.3569 |
| Pubmed ID | |
| Authors |
Saul A Villeda, Kristopher E Plambeck, Jinte Middeldorp, Joseph M Castellano, Kira I Mosher, Jian Luo, Lucas K Smith, Gregor Bieri, Karin Lin, Daniela Berdnik, Rafael Wabl, Joe Udeochu, Elizabeth G Wheatley, Bende Zou, Danielle A Simmons, Xinmin S Xie, Frank M Longo, Tony Wyss-Coray |
| Abstract |
As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the effects of aging. Here we report that exposure of an aged animal to young blood can counteract and reverse pre-existing effects of brain aging at the molecular, structural, functional and cognitive level. Genome-wide microarray analysis of heterochronic parabionts--in which circulatory systems of young and aged animals are connected--identified synaptic plasticity-related transcriptional changes in the hippocampus of aged mice. Dendritic spine density of mature neurons increased and synaptic plasticity improved in the hippocampus of aged heterochronic parabionts. At the cognitive level, systemic administration of young blood plasma into aged mice improved age-related cognitive impairments in both contextual fear conditioning and spatial learning and memory. Structural and cognitive enhancements elicited by exposure to young blood are mediated, in part, by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus. Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function. |
X Demographics
The data shown below were collected from the profiles of 785 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 116 | 15% |
| United States | 102 | 13% |
| United Kingdom | 30 | 4% |
| Italy | 15 | 2% |
| Canada | 8 | 1% |
| Turkey | 8 | 1% |
| Spain | 7 | <1% |
| Germany | 7 | <1% |
| France | 6 | <1% |
| Other | 66 | 8% |
| Unknown | 420 | 54% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 649 | 83% |
| Scientists | 87 | 11% |
| Practitioners (doctors, other healthcare professionals) | 32 | 4% |
| Science communicators (journalists, bloggers, editors) | 17 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,561 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 25 | 2% |
| United Kingdom | 8 | <1% |
| Japan | 7 | <1% |
| Spain | 6 | <1% |
| Germany | 4 | <1% |
| China | 4 | <1% |
| Brazil | 4 | <1% |
| Switzerland | 3 | <1% |
| Portugal | 3 | <1% |
| Other | 20 | 1% |
| Unknown | 1477 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 320 | 20% |
| Researcher | 315 | 20% |
| Student > Bachelor | 194 | 12% |
| Student > Master | 137 | 9% |
| Professor | 73 | 5% |
| Other | 278 | 18% |
| Unknown | 244 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 448 | 29% |
| Biochemistry, Genetics and Molecular Biology | 218 | 14% |
| Neuroscience | 200 | 13% |
| Medicine and Dentistry | 182 | 12% |
| Engineering | 45 | 3% |
| Other | 180 | 12% |
| Unknown | 288 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1796. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2024.
All research outputs
#5,744
of 25,782,917 outputs
Outputs from Nature Medicine
#91
of 9,433 outputs
Outputs of similar age
#22
of 243,001 outputs
Outputs of similar age from Nature Medicine
#1
of 101 outputs
Altmetric has tracked 25,782,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
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