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Transplacental transmission of Human Papillomavirus

Overview of attention for article published in Virology Journal, January 2008
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Title
Transplacental transmission of Human Papillomavirus
Published in
Virology Journal, January 2008
DOI 10.1186/1743-422x-5-106
Pubmed ID
Authors

Renato L Rombaldi, Eduardo P Serafini, Jovana Mandelli, Edineia Zimmermann, Kamille P Losquiavo

Abstract

This paper aimed at studying the transplacental transmission of HPV and looking at the epidemiological factors involved in maternal viral infection. The following sampling methods were used: (1) in the pregnant woman, (a) genital; (b) peripheral blood; (2) in the newborn, (a) oral cavity, axillary and inguinal regions; (b) nasopharyngeal aspirate, and (c) cord blood; (3) in the placenta. The HPV DNA was identified using two methods: multiplex PCR of human beta-globin and of HPV using the PGMY09 and PGMY11 primers; and nested-PCR, which combines degenerated primers of the E6/E7 regions of the HPV virus, that allowed the identification of genotypes 6/11, 16, 18, 31, 33, 42, 52 and 58. Transplacental transmission was considered when type-specific HPV concordance was found between the mother, the placenta and the newborn or the mother and cord blood. The study included 49 HPV DNA-positive pregnant women at delivery. Twelve placentas (24.5%, n = 12/49) had a positive result for HPV DNA. Eleven newborn were HPV DNA positive in samples from the nasopharyngeal or buccal and body or cord blood. In 5 cases (10.2%, n = 5/49) there was HPV type-specific agreement between genital/placenta/newborn samples. In one case (2%, n = 1/49) there was type specific HPV concordance between genital/cord blood and also suggested transplacental transmission. A positive and significant correlation was observed between transplacental transmission of HPV infection and the maternal variables of immunodepression history (HIV, p = 0.011). In conclusion the study suggests placental infection in 23.3% of the cases studied and transplacental transmission in 12.2%. It is suggested that in future HPV DNA be researched in the normal endometrium of women of reproductive age. The possible consequence of fetal exposure to HPV should be observed.

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 3%
United States 2 2%
Portugal 1 <1%
United Kingdom 1 <1%
Unknown 105 94%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 19 17%
Researcher 17 15%
Student > Ph. D. Student 14 13%
Student > Master 12 11%
Student > Bachelor 11 10%
Other 24 21%
Unknown 15 13%
Readers by discipline Count As %
Medicine and Dentistry 48 43%
Agricultural and Biological Sciences 16 14%
Biochemistry, Genetics and Molecular Biology 7 6%
Immunology and Microbiology 4 4%
Nursing and Health Professions 4 4%
Other 13 12%
Unknown 20 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2011.
All research outputs
#9,479,575
of 15,490,674 outputs
Outputs from Virology Journal
#1,343
of 2,401 outputs
Outputs of similar age
#47,034
of 73,868 outputs
Outputs of similar age from Virology Journal
#1
of 1 outputs
Altmetric has tracked 15,490,674 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,401 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 73,868 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them