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FGF23 regulates renal sodium handling and blood pressure

Overview of attention for article published in EMBO Molecular Medicine, May 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#28 of 542)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Readers on

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85 Mendeley
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Title
FGF23 regulates renal sodium handling and blood pressure
Published in
EMBO Molecular Medicine, May 2014
DOI 10.1002/emmm.201303716
Pubmed ID
Authors

Olena Andrukhova, Svetlana Slavic, Alina Smorodchenko, Ute Zeitz, Victoria Shalhoub, Beate Lanske, Elena E Pohl, Reinhold G Erben, Andrukhova O, Slavic S, Smorodchenko A, Zeitz U, Shalhoub V, Lanske B, Pohl EE, Erben RG, Andrukhova, Olena, Slavic, Svetlana, Smorodchenko, Alina, Zeitz, Ute, Shalhoub, Victoria, Lanske, Beate, Pohl, Elena E, Erben, Reinhold G

Abstract

Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Here, we show that FGF23 directly regulates the membrane abundance of the Na(+):Cl(-) co-transporter NCC in distal renal tubules by a signaling mechanism involving the FGF receptor/αKlotho complex, extracellular signal-regulated kinase 1/2 (ERK1/2), serum/glucocorticoid-regulated kinase 1 (SGK1), and with-no lysine kinase-4 (WNK4). Renal sodium (Na(+)) reabsorption and distal tubular membrane expression of NCC are reduced in mouse models of Fgf23 and αKlotho deficiency. Conversely, gain of FGF23 function by injection of wild-type mice with recombinant FGF23 or by elevated circulating levels of endogenous Fgf23 in Hyp mice increases distal tubular Na(+) uptake and membrane abundance of NCC, leading to volume expansion, hypertension, and heart hypertrophy in a αKlotho and dietary Na(+)-dependent fashion. The NCC inhibitor chlorothiazide abrogates FGF23-induced volume expansion and heart hypertrophy. Our findings suggest that FGF23 is a key regulator of renal Na(+) reabsorption and plasma volume, and may explain the association of FGF23 with cardiovascular risk in chronic kidney disease patients.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 4 5%
United Kingdom 2 2%
France 1 1%
Italy 1 1%
Hungary 1 1%
Korea, Republic of 1 1%
Netherlands 1 1%
Unknown 74 87%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 19%
Student > Ph. D. Student 15 18%
Student > Bachelor 9 11%
Other 9 11%
Professor > Associate Professor 8 9%
Other 28 33%
Readers by discipline Count As %
Medicine and Dentistry 34 40%
Agricultural and Biological Sciences 26 31%
Biochemistry, Genetics and Molecular Biology 9 11%
Unspecified 6 7%
Chemistry 2 2%
Other 8 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 71. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2014.
All research outputs
#86,363
of 6,580,471 outputs
Outputs from EMBO Molecular Medicine
#28
of 542 outputs
Outputs of similar age
#3,041
of 149,817 outputs
Outputs of similar age from EMBO Molecular Medicine
#1
of 18 outputs
Altmetric has tracked 6,580,471 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 149,817 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.