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FGF23 regulates renal sodium handling and blood pressure

Overview of attention for article published in EMBO Molecular Medicine, May 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#49 of 854)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Citations

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Readers on

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105 Mendeley
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Title
FGF23 regulates renal sodium handling and blood pressure
Published in
EMBO Molecular Medicine, May 2014
DOI 10.1002/emmm.201303716
Pubmed ID
Authors

Olena Andrukhova, Svetlana Slavic, Alina Smorodchenko, Ute Zeitz, Victoria Shalhoub, Beate Lanske, Elena E Pohl, Reinhold G Erben

Abstract

Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Here, we show that FGF23 directly regulates the membrane abundance of the Na(+):Cl(-) co-transporter NCC in distal renal tubules by a signaling mechanism involving the FGF receptor/αKlotho complex, extracellular signal-regulated kinase 1/2 (ERK1/2), serum/glucocorticoid-regulated kinase 1 (SGK1), and with-no lysine kinase-4 (WNK4). Renal sodium (Na(+)) reabsorption and distal tubular membrane expression of NCC are reduced in mouse models of Fgf23 and αKlotho deficiency. Conversely, gain of FGF23 function by injection of wild-type mice with recombinant FGF23 or by elevated circulating levels of endogenous Fgf23 in Hyp mice increases distal tubular Na(+) uptake and membrane abundance of NCC, leading to volume expansion, hypertension, and heart hypertrophy in a αKlotho and dietary Na(+)-dependent fashion. The NCC inhibitor chlorothiazide abrogates FGF23-induced volume expansion and heart hypertrophy. Our findings suggest that FGF23 is a key regulator of renal Na(+) reabsorption and plasma volume, and may explain the association of FGF23 with cardiovascular risk in chronic kidney disease patients.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 4 4%
Italy 1 <1%
United Kingdom 1 <1%
France 1 <1%
Hungary 1 <1%
Korea, Republic of 1 <1%
Netherlands 1 <1%
Unknown 95 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 19%
Student > Ph. D. Student 17 16%
Other 12 11%
Student > Bachelor 11 10%
Student > Doctoral Student 10 10%
Other 35 33%
Readers by discipline Count As %
Medicine and Dentistry 43 41%
Agricultural and Biological Sciences 28 27%
Biochemistry, Genetics and Molecular Biology 12 11%
Unspecified 8 8%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 10 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 72. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2018.
All research outputs
#192,925
of 12,225,951 outputs
Outputs from EMBO Molecular Medicine
#49
of 854 outputs
Outputs of similar age
#3,735
of 198,820 outputs
Outputs of similar age from EMBO Molecular Medicine
#1
of 22 outputs
Altmetric has tracked 12,225,951 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 854 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,820 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.