Title |
European Adrenal Insufficiency Registry (EU-AIR): a comparative observational study of glucocorticoid replacement therapy
|
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Published in |
BMC Endocrine Disorders, May 2014
|
DOI | 10.1186/1472-6823-14-40 |
Pubmed ID | |
Authors |
Bertil Ekman, David Fitts, Claudio Marelli, Robert D Murray, Marcus Quinkler, Pierre MJ Zelissen |
Abstract |
Increased morbidity and mortality associated with conventional glucocorticoid replacement therapy for primary adrenal insufficiency (primary AI; estimated prevalence 93-140/million), secondary AI (estimated prevalence, 150-280/million, respectively) or congenital adrenal hyperplasia (estimated prevalence, approximately 65/million) may be due to the inability of typical glucocorticoid treatment regimens to reproduce the normal circadian profile of plasma cortisol. A once-daily modified-release formulation of hydrocortisone has been developed to provide a plasma cortisol profile that better mimics the daytime endogenous profile of cortisol. Here, we describe the protocol for the European Adrenal Insufficiency Registry (EU-AIR), an observational study to assess the long-term safety of modified-release hydrocortisone compared with conventional glucocorticoid replacement therapies in routine clinical practice (ClinicalTrials.gov identifier: NCT01661387). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 65 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 11 | 17% |
Researcher | 10 | 15% |
Student > Bachelor | 9 | 14% |
Student > Master | 9 | 14% |
Student > Ph. D. Student | 5 | 8% |
Other | 6 | 9% |
Unknown | 15 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 35 | 54% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Chemistry | 2 | 3% |
Nursing and Health Professions | 1 | 2% |
Other | 5 | 8% |
Unknown | 15 | 23% |