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DNA Damage in Buccal Mucosa Cells of Pre-School Children Exposed to High Levels of Urban Air Pollutants

Overview of attention for article published in PLOS ONE, May 2014
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Title
DNA Damage in Buccal Mucosa Cells of Pre-School Children Exposed to High Levels of Urban Air Pollutants
Published in
PLOS ONE, May 2014
DOI 10.1371/journal.pone.0096524
Pubmed ID
Authors

Elisabetta Ceretti, Donatella Feretti, Gaia C V. Viola, Ilaria Zerbini, Rosa M. Limina, Claudia Zani, Michela Capelli, Rossella Lamera, Francesco Donato, Umberto Gelatti

Abstract

Air pollution has been recognized as a human carcinogen. Children living in urban areas are a high-risk group, because genetic damage occurring early in life is considered able to increase the risk of carcinogenesis in adulthood. This study aimed to investigate micronuclei (MN) frequency, as a biomarker of DNA damage, in exfoliated buccal cells of pre-school children living in a town with high levels of air pollution. A sample of healthy 3-6-year-old children living in Brescia, Northern Italy, was investigated. A sample of the children's buccal mucosa cells was collected during the winter months in 2012 and 2013. DNA damage was investigated using the MN test. Children's exposure to urban air pollution was evaluated by means of a questionnaire filled in by their parents that included items on various possible sources of indoor and outdoor pollution, and the concentration of fine particulate matter (PM10, PM2.5) and NO2 in the 1-3 weeks preceding biological sample collection. 181 children (mean age ± SD: 4.3 ± 0.9 years) were investigated. The mean ± SD MN frequency was 0.29 ± 0.13%. A weak, though statistically significant, association of MN with concentration of air pollutants (PM10, PM2.5 and NO2) was found, whereas no association was apparent between MN frequency and the indoor and outdoor exposure variables investigated via the questionnaire. This study showed a high MN frequency in children living in a town with heavy air pollution in winter, higher than usually found among children living in areas with low or medium-high levels of air pollution.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 1%
Unknown 93 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 26%
Student > Ph. D. Student 10 11%
Student > Master 8 9%
Student > Bachelor 7 7%
Student > Postgraduate 4 4%
Other 14 15%
Unknown 27 29%
Readers by discipline Count As %
Environmental Science 20 21%
Medicine and Dentistry 16 17%
Nursing and Health Professions 6 6%
Agricultural and Biological Sciences 4 4%
Biochemistry, Genetics and Molecular Biology 4 4%
Other 12 13%
Unknown 32 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2014.
All research outputs
#15,300,431
of 22,755,127 outputs
Outputs from PLOS ONE
#130,428
of 194,177 outputs
Outputs of similar age
#134,205
of 227,755 outputs
Outputs of similar age from PLOS ONE
#3,012
of 4,849 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,177 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,755 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,849 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.