Title |
Regulation of Cellular Metabolism by Protein Lysine Acetylation
|
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Published in |
Science, February 2010
|
DOI | 10.1126/science.1179689 |
Pubmed ID | |
Authors |
Shimin Zhao, Wei Xu, Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao, Li Zhou, Yaxue Zeng, Hong Li, Yixue Li, Jiong Shi, Wenlin An, Susan M. Hancock, Fuchu He, Lunxiu Qin, Jason Chin, Pengyuan Yang, Xian Chen, Qunying Lei, Yue Xiong, Kun-Liang Guan |
Abstract |
Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the modification of histones and nuclear transcription regulators. We show that lysine acetylation is a prevalent modification in enzymes that catalyze intermediate metabolism. Virtually every enzyme in glycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, the urea cycle, fatty acid metabolism, and glycogen metabolism was found to be acetylated in human liver tissue. The concentration of metabolic fuels, such as glucose, amino acids, and fatty acids, influenced the acetylation status of metabolic enzymes. Acetylation activated enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase in fatty acid oxidation and malate dehydrogenase in the TCA cycle, inhibited argininosuccinate lyase in the urea cycle, and destabilized phosphoenolpyruvate carboxykinase in gluconeogenesis. Our study reveals that acetylation plays a major role in metabolic regulation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 23 | 2% |
United Kingdom | 7 | <1% |
Germany | 4 | <1% |
Japan | 3 | <1% |
Brazil | 3 | <1% |
Netherlands | 2 | <1% |
Switzerland | 2 | <1% |
Spain | 2 | <1% |
Belgium | 2 | <1% |
Other | 20 | 2% |
Unknown | 955 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 279 | 27% |
Researcher | 209 | 20% |
Student > Master | 110 | 11% |
Student > Bachelor | 81 | 8% |
Professor > Associate Professor | 57 | 6% |
Other | 151 | 15% |
Unknown | 136 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 414 | 40% |
Biochemistry, Genetics and Molecular Biology | 263 | 26% |
Chemistry | 54 | 5% |
Medicine and Dentistry | 51 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 19 | 2% |
Other | 82 | 8% |
Unknown | 140 | 14% |