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Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study

Overview of attention for article published in Alzheimer's Research & Therapy, August 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 1,494)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
100 news outlets
blogs
2 blogs
twitter
26 X users
facebook
5 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
202 Dimensions

Readers on

mendeley
305 Mendeley
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Title
Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study
Published in
Alzheimer's Research & Therapy, August 2017
DOI 10.1186/s13195-017-0282-6
Pubmed ID
Authors

Chang-Kai Chen, Yung-Tsan Wu, Yu-Chao Chang

Abstract

Although recent short-term cross-sectional studies have revealed that chronic periodontitis (CP) may be a risk factor for increased cognitive impairment in patients with Alzheimer's disease (AD), systematic reviews and long-term longitudinal studies have provided less clear evidence regarding the relationship between CP and AD. Therefore, we conducted a retrospective cohort study using the National Health Insurance Research Database (NHIRD) of Taiwan to determine whether patients with CP are at increased risk of developing AD. We conducted a retrospective matched-cohort study using the NHIRD of Taiwan. We identified 9291 patients newly diagnosed with CP between 1997 and 2004. A total of 18,672 patients without CP were matched to the patient cohort according to sex, age, index year, co-morbidity and urbanisation level. Cox proportional hazards regression analyses were performed to evaluate the subsequent risk of AD. Patients with CP had a higher prevalence of hyperlipidaemia, depression, traumatic brain injury and co-morbidities, as well as higher urbanisation levels, than those in the unexposed cohort (all p < 0.01). At the final follow-up, totals of 115 (1.24%) and 208 (1.11%) individuals in the CP exposed and unexposed groups, respectively, had developed AD. Patients with 10 years of CP exposure exhibited a higher risk of developing AD than unexposed groups (adjusted HR 1.707, 95% CI 1.152-2.528, p = 0.0077). Our findings demonstrate that 10-year CP exposure was associated with a 1.707-fold increase in the risk of developing AD. These findings highlight the need to prevent progression of periodontal disease and promote healthcare service at the national level.

X Demographics

X Demographics

The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 305 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 305 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 44 14%
Student > Master 33 11%
Student > Postgraduate 29 10%
Student > Ph. D. Student 27 9%
Researcher 23 8%
Other 43 14%
Unknown 106 35%
Readers by discipline Count As %
Medicine and Dentistry 100 33%
Nursing and Health Professions 15 5%
Biochemistry, Genetics and Molecular Biology 14 5%
Neuroscience 14 5%
Agricultural and Biological Sciences 12 4%
Other 37 12%
Unknown 113 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 803. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2023.
All research outputs
#23,815
of 25,837,817 outputs
Outputs from Alzheimer's Research & Therapy
#4
of 1,494 outputs
Outputs of similar age
#426
of 329,628 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#1
of 33 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,494 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,628 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.