Chapter title |
Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock.
|
---|---|
Chapter number | 30 |
Book title |
Brain Edema X
|
Published in |
Acta neurochirurgica Supplement, January 1997
|
DOI | 10.1007/978-3-7091-6837-0_30 |
Pubmed ID | |
Book ISBNs |
978-3-70-917418-0, 978-3-70-916837-0
|
Authors |
Bell, M J, Kochanek, P M, Doughty, L A, Carcillo, J A, Adelson, P D, Clark, R S, Whalen, M J, DeKosky, S T, M. J. Bell, Patrick M. Kochanek, L. A. Doughty, J. A. Carcillo, P. D. Adelson, R. S. B. Clark, M. J. Whalen, S. T. DeKosky, Bell, M. J., Kochanek, Patrick M., Doughty, L. A., Carcillo, J. A., Adelson, P. D., Clark, R. S. B., Whalen, M. J., DeKosky, S. T. |
Abstract |
Inflammation may play an important role in the evolution of damage after traumatic brain injury (TBI). IL-6 and IL-10 are markers of inflammation that are pro- and anti-inflammatory in nature, respectively. They have been used as an index of the degree of inflammation in diseases including sepsis and meningitis. We hypothesized that both IL-6 and IL-10 would be increased in the cerebrospinal fluid (CSF) of children after TBI. We measured ventricular CSF concentrations of these metabolites (ELISA) each of the first 3 days after TBI in 15 children. CSF IL-6 was increased on day 1 (p < 0.05 vs days 2 or 3). CSF IL-10 was similarly increased on day 1 (p < 0.05). CSF IL-6 after TBI is similar to serum IL-6 levels previously reported in children with septic shock. In contrast, the CSF IL-10 response was markedly attenuated following TBI compared to sepsis. These data suggest a unique balance between pro- and anti-inflammatory cytokines in brain after TBI. |
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Demographic breakdown
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Student > Postgraduate | 3 | 12% |
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