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Altered Pharmacokinetics of Piperacillin in Febrile Neutropenic Patients with Hematological Malignancy

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, March 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

twitter
4 tweeters

Citations

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20 Dimensions

Readers on

mendeley
16 Mendeley
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Title
Altered Pharmacokinetics of Piperacillin in Febrile Neutropenic Patients with Hematological Malignancy
Published in
Antimicrobial Agents and Chemotherapy, March 2014
DOI 10.1128/aac.02340-14
Pubmed ID
Authors

Fekade Bruck Sime, Michael S. Roberts, Morgyn S. Warner, Uwe Hahn, Thomas A. Robertson, Sue Yeend, Andy Phay, Sheila Lehman, Jeffrey Lipman, Sandra L. Peake, Jason A. Roberts

Abstract

This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7 ± 8.0 liters [mean ± standard deviation]) and clearance (20.2 ± 7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 31%
Student > Ph. D. Student 3 19%
Other 2 13%
Student > Bachelor 2 13%
Student > Master 2 13%
Other 1 6%
Unknown 1 6%
Readers by discipline Count As %
Medicine and Dentistry 12 75%
Pharmacology, Toxicology and Pharmaceutical Science 3 19%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2015.
All research outputs
#6,359,371
of 12,358,913 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#8,593
of 11,171 outputs
Outputs of similar age
#67,810
of 193,525 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#66
of 258 outputs
Altmetric has tracked 12,358,913 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,171 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,525 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 258 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.