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RETRACTED ARTICLE:Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives

Overview of attention for article published in Nature Communications, August 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
23 news outlets
blogs
4 blogs
twitter
64 tweeters
facebook
16 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
56 Mendeley
Title
RETRACTED ARTICLE:Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives
Published in
Nature Communications, August 2017
DOI 10.1038/s41467-017-00254-8
Pubmed ID
Authors

Uthra Rajamani, Andrew R. Gross, Camille Ocampo, Allen M. Andres, Roberta A. Gottlieb, Dhruv Sareen

Abstract

Persistent exposure to man-made endocrine disrupting chemicals during fetal endocrine development may lead to disruption of metabolic homeostasis contributing to childhood obesity. Limited cellular platforms exist to test endocrine disrupting chemical-induced developmental abnormalities in human endocrine tissues. Here we use an human-induced pluripotent stem cell-based platform to demonstrate adverse impacts of obesogenic endocrine disrupting chemicals in the developing endocrine system. We delineate the effects upon physiological low-dose exposure to ubiquitous endocrine disrupting chemicals including, perfluoro-octanoic acid, tributyltin, and butylhydroxytoluene, in endocrine-active human-induced pluripotent stem cell-derived foregut epithelial cells and hypothalamic neurons. Endocrine disrupting chemicals induce endoplasmic reticulum stress, perturb NF-κB, and p53 signaling, and diminish mitochondrial respiratory gene expression, spare respiratory capacity, and ATP levels. As a result, normal production and secretion of appetite control hormones, PYY, α-MSH, and CART, are hampered. Blocking NF-κB rescues endocrine disrupting chemical-induced aberrant mitochondrial phenotypes and endocrine dysregulation, but not ER-stress and p53-phosphorylation changes.Harmful chemicals that disrupt the endocrine system and hormone regulation have been associated with obesity. Here the authors apply a human pluripotent stem cell-based platform to study the effects of such compounds on developing gut endocrine and neuroendocrine systems.

Twitter Demographics

The data shown below were collected from the profiles of 64 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 21%
Student > Ph. D. Student 8 14%
Student > Bachelor 7 13%
Student > Master 7 13%
Student > Doctoral Student 5 9%
Other 6 11%
Unknown 11 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 27%
Biochemistry, Genetics and Molecular Biology 9 16%
Medicine and Dentistry 7 13%
Chemistry 3 5%
Environmental Science 2 4%
Other 7 13%
Unknown 13 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 237. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2019.
All research outputs
#55,285
of 13,770,158 outputs
Outputs from Nature Communications
#812
of 25,218 outputs
Outputs of similar age
#2,664
of 267,383 outputs
Outputs of similar age from Nature Communications
#33
of 982 outputs
Altmetric has tracked 13,770,158 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,218 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,383 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 982 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.