Chapter title |
Molecular Malfeasance Mediating Myeloid Malignancies: The Genetics of Acute Myeloid Leukemia
|
---|---|
Chapter number | 1 |
Book title |
Acute Myeloid Leukemia
|
Published in |
Methods in molecular biology, July 2017
|
DOI | 10.1007/978-1-4939-7142-8_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7140-4, 978-1-4939-7142-8
|
Authors |
King, Rebecca L., Bagg, Adam, Rebecca L. King, Adam Bagg |
Abstract |
A remarkable number of different, but recurrent, structural cytogenetic abnormalities have been observed in AML, and the 2016 WHO AML classification system incorporates numerous distinct entities associated with translocations or inversions, as well as others associated with single gene mutations into a category entitled "AML with recurrent genetic abnormalities." The AML classification is heavily reliant on cytogenetic and molecular information based on conventional genetic techniques (including karyotype, fluorescence in situ hybridization, reverse transcriptase polymerase chain reaction, single gene sequencing), but large-scale next generation sequencing is now identifying novel mutations. With targeted next generation sequencing panels now clinically available at many centers, detection of mutations, as well as alterations in epigenetic modifiers, is becoming part of the routine diagnostic evaluation of AML and will likely impact future classification schemes. |
X Demographics
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United States | 4 | 100% |
Demographic breakdown
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Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 1 | 13% |
Student > Ph. D. Student | 1 | 13% |
Researcher | 1 | 13% |
Unknown | 5 | 63% |
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Biochemistry, Genetics and Molecular Biology | 2 | 25% |
Medicine and Dentistry | 1 | 13% |
Unknown | 5 | 63% |