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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mitochondrial oxidative stress in aging and healthspan
|
|---|---|
| Published in |
Longevity & Healthspan, May 2014
|
| DOI | 10.1186/2046-2395-3-6 |
| Pubmed ID | |
| Authors |
Dao-Fu Dai, Ying Ann Chiao, David J Marcinek, Hazel H Szeto, Peter S Rabinovitch |
| Abstract |
The free radical theory of aging proposes that reactive oxygen species (ROS)-induced accumulation of damage to cellular macromolecules is a primary driving force of aging and a major determinant of lifespan. Although this theory is one of the most popular explanations for the cause of aging, several experimental rodent models of antioxidant manipulation have failed to affect lifespan. Moreover, antioxidant supplementation clinical trials have been largely disappointing. The mitochondrial theory of aging specifies more particularly that mitochondria are both the primary sources of ROS and the primary targets of ROS damage. In addition to effects on lifespan and aging, mitochondrial ROS have been shown to play a central role in healthspan of many vital organ systems. In this article we review the evidence supporting the role of mitochondrial oxidative stress, mitochondrial damage and dysfunction in aging and healthspan, including cardiac aging, age-dependent cardiovascular diseases, skeletal muscle aging, neurodegenerative diseases, insulin resistance and diabetes as well as age-related cancers. The crosstalk of mitochondrial ROS, redox, and other cellular signaling is briefly presented. Potential therapeutic strategies to improve mitochondrial function in aging and healthspan are reviewed, with a focus on mitochondrial protective drugs, such as the mitochondrial antioxidants MitoQ, SkQ1, and the mitochondrial protective peptide SS-31. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 29% |
| Finland | 1 | 14% |
| Spain | 1 | 14% |
| Chile | 1 | 14% |
| Canada | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Science communicators (journalists, bloggers, editors) | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 367 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| United Kingdom | 3 | <1% |
| South Africa | 2 | <1% |
| Brazil | 1 | <1% |
| India | 1 | <1% |
| Portugal | 1 | <1% |
| Mexico | 1 | <1% |
| Germany | 1 | <1% |
| Russia | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 351 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 69 | 19% |
| Researcher | 61 | 17% |
| Student > Bachelor | 50 | 14% |
| Student > Master | 48 | 13% |
| Student > Doctoral Student | 21 | 6% |
| Other | 68 | 19% |
| Unknown | 50 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 113 | 31% |
| Biochemistry, Genetics and Molecular Biology | 68 | 19% |
| Medicine and Dentistry | 47 | 13% |
| Neuroscience | 17 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 2% |
| Other | 50 | 14% |
| Unknown | 64 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2024.
All research outputs
#2,054,880
of 25,744,802 outputs
Outputs from Longevity & Healthspan
#9
of 25 outputs
Outputs of similar age
#19,993
of 243,015 outputs
Outputs of similar age from Longevity & Healthspan
#1
of 4 outputs
Altmetric has tracked 25,744,802 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.4. This one scored the same or higher as 16 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,015 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them