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Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers

Overview of attention for article published in Carcinogenesis, May 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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7 tweeters

Citations

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49 Dimensions

Readers on

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57 Mendeley
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Title
Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers
Published in
Carcinogenesis, May 2014
DOI 10.1093/carcin/bgu114
Pubmed ID
Authors

Tiffany A. Wallace, Ronan F. Downey, Caleb J. Seufert, Aaron Schetter, Tiffany H. Dorsey, Carol A. Johnson, Radoslav Goldman, Christopher A. Loffredo, Peisha Yan, Francis J. Sullivan, Francis J. Giles, Feng Wang-Johanning, Stefan Ambs, Sharon A. Glynn

Abstract

Aberrant expression of subgroup k human endogenous retroviruses (HERV-K) has been observed in prostate cancer. This subgroup is unique because it encodes sequences in the human genome containing open reading frames for near intact retroviruses. We hypothesized that HERV-K reactivation could serve as a non-invasive early disease detection marker for prostate cancer. We evaluated HERV-K gag mRNA expression in blood samples of African-American and European-American men using a case-control design via qRT-PCR. Additionally we examined HERV-K envelope protein expression in prostate tumors by immunohistochemistry. HERV-K envelope protein was commonly up-regulated in prostate tumors, but more so in tumors of African-American than European-American patients (61% versus 40%, P < 0.01). Examining HERV-K gag expression in peripheral blood mononuclear cells from 294 cases and 135 healthy men, we found that the abundance of HERV-K gag message was significantly higher in cases than controls, and was associated with increased plasma IFNγ. Men with gag expression in the highest quartile had a greater than 12-fold increased odds [odds ratio = 12.87 (95% CI 6.3-26.25)] of being diagnosed with prostate cancer than those in the lowest quartile. Moreover, our results showed that HERV-K expression may perform better as a disease biomarker in older than younger men (whereas the sensitivity of PSA testing decreases with age), and in men with a smoking history compared with never smokers. Combining non-invasive HERV-K testing with PSA testing may improve the efficacy of prostate cancer detection specifically among older men and smokers who tend to develop a more aggressive disease.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
Brazil 1 2%
Unknown 55 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 25%
Student > Ph. D. Student 12 21%
Student > Master 9 16%
Student > Bachelor 7 12%
Student > Doctoral Student 4 7%
Other 6 11%
Unknown 5 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 28%
Biochemistry, Genetics and Molecular Biology 11 19%
Medicine and Dentistry 6 11%
Immunology and Microbiology 5 9%
Chemistry 4 7%
Other 5 9%
Unknown 10 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2020.
All research outputs
#4,202,184
of 17,635,820 outputs
Outputs from Carcinogenesis
#1,134
of 4,435 outputs
Outputs of similar age
#42,482
of 197,152 outputs
Outputs of similar age from Carcinogenesis
#5
of 31 outputs
Altmetric has tracked 17,635,820 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,435 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,152 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.