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Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs.

Overview of attention for article published in Biomaterials, August 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#36 of 2,444)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
9 news outlets
blogs
2 blogs
twitter
1 tweeter
facebook
1 Facebook page

Readers on

mendeley
28 Mendeley
Title
Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs.
Published in
Biomaterials, August 2014
DOI 10.1016/j.biomaterials.2014.05.004
Pubmed ID
Authors

Wanyi Tai, Ran Mo, Yue Lu, Tianyue Jiang, Zhen Gu

Abstract

A graft copolymer with pendant drug segments can fold into nanostructures in a protein folding-like manner. The graft copolymer is constructed by directly polymerizing γ-camptothecin-glutamate N-carboxyanhydride (Glu(CPT)-NCA) on multiple sites of poly(ethylene glycol) (PEG)-based main chain via the ring open polymerization (ROP). The "purely" conjugated anticancer agent camptothecin (CPT) is hydrophobic and serves as the principal driving force during the folding process. When exposed to water, the obtained copolymer, together with doxorubicin (Dox), another anticancer agent, can fold into monodispersed nanocarriers (with a diameter of around 50 nm) for dual-drug delivery. Equipped with a PEG shell, the nanocarriers displayed good stability and can be internalized by a variety of cancer cell lines via the lipid raft and clathrin-mediated endocytotic pathway without premature leakage, which showed a high synergetic activity of CPT and Dox toward various cancer cells. In vivo study validated that the nanocarriers exhibited strong accumulation in tumor sites and showed a prominent anticancer activity against the lung cancer xenograft mice model compared with free drugs.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 43%
Student > Doctoral Student 4 14%
Researcher 4 14%
Student > Bachelor 2 7%
Student > Master 2 7%
Other 4 14%
Readers by discipline Count As %
Chemistry 10 36%
Unspecified 4 14%
Medicine and Dentistry 4 14%
Agricultural and Biological Sciences 3 11%
Materials Science 3 11%
Other 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2016.
All research outputs
#113,982
of 8,223,523 outputs
Outputs from Biomaterials
#36
of 2,444 outputs
Outputs of similar age
#3,023
of 176,802 outputs
Outputs of similar age from Biomaterials
#1
of 76 outputs
Altmetric has tracked 8,223,523 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,444 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,802 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.